文献_balanced translocation hot spot.pdfVIP

This article is authors’ accepted manuscripts in Asian Journal of Andrology. OnlineFirst Author’s accepted Manuscripts are PDF versions of manuscripts that have been peer reviewed and accepted for publication, but not yet copyedited or typeset and is not the final version for publication, allowing readers the most rapid access to accepted papers. They appear on the OnlineFirst page as submitted by the authors, subject to the authors agreement, and do not reflect the changes that will be made before final publication. The Author Manuscript remains on the OnlineFirst page until it is either replaced by the final proof version or when the final version of the paper is published in an online issue. Letter to the editor A rare complex chromosomal rearrangement in an oligospermic male: a case report and review of the Chinese literature Ying-Jian Chen, Wei-Wei Zhang, Xiao-Ming Sun and Cheng-Jin Hu Department of Laboratory Medicine, General Hospital of Jinan Military Area, Jinan 250031 China Correspondence: Dr CJ Hu (med-lab@) Asian Journal of Andrology advance online publication, ****; doi:***** Received: 1 June 2013; Revised: 16 July 2013; Accepted: 8 August 2013 Dear Editor, Complex chromosome rearrangements (CCRs) are structural aberrations involving at least three chromosomes with three or more chromosomal breakpoints. CCRs are very rare events in the human population. As reviewed by Pellestor et al.,1 less than 255 cases of CCRs involving three or more chromosomes have been reported. In China, approximately 136 cases of CCRs, including 40 males with reproductive problems, have been reported up to the time this review was compiled. CCRs have been classified into three major categories, according to their structure: t