Acetylation Targets the M2 Isoform of Pyruvate;复旦大学14.6分，PSA抗体教程.pdfVIP

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Acetylation Targets the M2 Isoform of Pyruvate;复旦大学14.6分，PSA抗体教程.pdf

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Molecular Cell Article Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth Lei Lv,1,3,4 Dong Li,5,10 Di Zhao,3,4,10 Ruiting Lin,3,4 Yajing Chu,6 Heng Zhang,1,3,4 Zhengyu Zha,3 Ying Liu,2 Zi Li,7 Yanping Xu,3,4 Gang Wang,6 Yiran Huang,5 Yue Xiong,3,4,8 Kun-Liang Guan,1,3,9 and Qun-Ying Lei1,3,* 1Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology 2Department of Pathology Shanghai Medical College, Fudan University, Shanghai 200032, China 3Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China 4School of Life Science, Fudan University, Shanghai 200433, China 5Department of Urology, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai 200127, China 6Institute of Biochemistry and Cell Biology 7Institute for Nutritional Sciences Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China 8Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA 9Department of Pharmacology and Moores Cancer Center, University of California at San Diego, La Jolla, CA 92093-0815, USA 10These authors contributed equally to this work *Correspondence: qlei@fudan.edu.cn DOI 10.1016/j.molcel.2011.04.025 SUMMARY ence of sufﬁcient oxygen supply (Warburg, 1956). Based on the dramatically increased glucose consumption in cancer cells, Most tumor cells take up more glucose than normal positron emission tomography (PET) of 2-(18F)-ﬂuoro-2-deoxy- cells but metabolize glucose via glycolysis even in D-glucose (FDG) has been developed as a diagnostic technique