人成釉细胞瘤中端粒酶活性与细胞周期素A 的表达.pdfVIP

2003 7 38 4 Ch in J Stomat ol, July 2003, V ol 38, No . 4 257 A 钟鸣 岳阳丽 王洁 王兆元 ! hT ERT ( ameloblastoma, AB) A ( cy clin A ) p53 ( pr oli eration cell nuclear antig en , PCN A) , ( SP ) AB Ap53 PCNA , hT ERT m RNA , ( odontog enic keratocyst , O KC) 1 hT ERT ( 1/ 7) , cyclin Ap53 PCN A OKC , 14 hT ERT ( 14/ 16) , 4 cyclin A ( 4/ 32) 11 p53 ( 11/ 25) , 5 PCN A ( 5/ 9) hT ERT m RNA AB 944 % ( 5 1/ 54) , cyclin A 667% ( 40/ 60) , p53 857% ( 42/ 49) , PCNA 7 81% ( 25/ 32) , hT ERT cyclin Ap53 PCNA Kendall , r 09 14 084 80804, P 005 , hT ERT m RN A s cyclin Ap53 PCN A AB p53 , , cyclin A , S ! ; , ; p53; Expression of telomerase activity and cyclin A in ameloblastoma ZHONG Ming , YUE Yangli, WAN G Jie, WANG Zhaoyuan Dep artment of Pathology, ollege of Stomatology, hina Medical University , Shenyang 110002, hina Abstract! Obj ective T o study relation o the expression o hT ERT m RNA and cyclin A , p53 protein, pr oli eration cell nuclear ant igen ( P CN A ) in ameloblastoma ( A B) and to investigate clinical biolog ical characteristics o AB Methods T he hT ERT m RN A w as detected by in situ hybridization , cyclin A, p53 protein and PCN A by SP method Normal oral mucosa and odontogenic keratocyst ( OK C) are comparition Results T he positive ratio o hT ERT m R NA w as 1/ 7 cases in normal oral mucosa T he ex pression o cyclin A, p53 and PCN A in normal oral mucosa w ere similar, and t he positiv e cells distributed in st ratum basale I n OK C, the posit ive cells distributed in stratum basale and superstrr tum basale And t he positiv e ratio o hT ERT , cyclin A , p53, PCNA in OK C w a