胸腺五肽对严重烧伤的免疫调节作用.pdfVIP

2·98 · 中华烧伤杂志2001 年 10 月第 17 卷第 5 期　Chin J Bu rns ,October 2001 ,Vol. 17 ,No. 5 ·论著· 胸腺五肽对严重烧伤的免疫调节作用 辛国华 　曾元临 　李国辉 　肖长辉 　余於荣 　毛远桂 ( ) 　　【摘要】　目的 　探讨胸腺五肽 Thym opentin , TP5 对严重烧伤患者 T 淋巴细胞亚群及 N K 细 ( ) ( ) 胞的影响。　方法 　检测治疗组 30 例 和对照组 30 例 患者伤后不同时间的外周血 T 淋巴细胞亚 群及 N K 细胞。治疗组从伤后第 2 天起接受 TP5 治疗 ,1 mg/ d ,肌肉注射 ,疗程 20 d ;对照组不使用 TP5 。　结果 　烧伤后第 2 天 ,两组患者 T 淋巴细胞及 N K 细胞差异无显著性意义。烧伤后第 5 、8 、 15 、22 天 ,两组 T 淋巴细胞总数差异无显著性意义 ,但对照组 N K 细胞数量及 CD4/ CD8 比值显著低 于治疗组。　结论 　胸腺五肽能明显提高和改善严重烧伤患者 T 淋巴细胞及 N K 细胞功能 ,起到良 好的免疫调节作用。 【关键词】　胸腺五肽 ; 　流式细胞术 ; 　免疫 功能调节 Modulating effects of thymopentin on the immune system of severely burned patien ts 　XIN Guohua , ZEN G Yuanlin ,L I Guohui ,et al. Burn Center , The First Affiliated Hospital of Jiangxi Medical College ,Nan Chang 330006 ,Jiang Xi Province ,P. R. China 【Abstract 】　Objective 　 To explore the modu lating effects of thymopentin ( TP5) on the immune system of severely bu rned patients. 　Methods 　Sixty patients with severe burn were enrolled in this study and were randomly divided into treatment ( T ,n = 30) and control ( C ,n = 30) groups. The T lym phocytes and N K cells in peripheral blood in two groups were determined on the 2 ,5 ,8 ,15 and 22 postburn days ( PBDs) . The patients in T group were treated with TP5 in a dose of 1mg/ d for 20 days begining on 2 PBD. 　Results There was no difference of T lymphocytes and N K cells between the two groups on 2 PBD , and there was no difference of total number in T lymphocytes between the two groups on 5 ,8 ,15and 22 PBDs. But the N K cell number and CD4/ CD8 ratio in C group were much lower than those in T group. 　 Conclusion 　The function of T lymphocytes and N