STAMPEDEPATIENTINFORMATIONSHEET-GENERAL：sheet-general踩踏患者信息.docVIP

STAMPEDE: PATIENT INFORMATION SHEET-GENERAL: PART 1 (to be printed on local hospital headed paper) Version 10.1 (February 2014) A LARGE PRINT VERSION IS AVAILABLE ON REQUEST STAMPEDE: Systemic Therapy in Advancing or Metastatic Prostate Cancer - Evaluation of Drug Efficacy General Information Your doctor has explained to you that you have prostate cancer and has invited you to participate in this clinical trial. Before you decide, it is important for you to understand why the research is being done and what it will involve. Participation is entirely voluntary. If you decide not to take part, your decision will be accepted without question, and your subsequent treatment will not be affected in any way. This sheet should be read with the “General Patient Information Sheet - Part 2” and treatment specific sheets. Why is this research being done? This study is called STAMPEDE and looks at the effect of combining one or two of these newer treatments described above with standard hormone treatment. Prostate cancer often depends upon the male hormone testosterone to grow. One of the main ways of treating prostate cancer involves hormonal treatment to reduce the level of testosterone in the body. This is achieved by using a range of drugs which reduce the signals to the testicles so they do not make the hormone, or by surgically removing the part of the testicles that produces testosterone. Some men may also have RT as part of their standard therapy. Hormone treatment is usually successful at first: further growth of the cancer is prevented and it will usually cause the cancer to shrink. However, after a period of time the cancer can begin to grow again. Nowadays, this type of prostate cancer is usually called castrate-refractory prostate cancer and is often abbreviated to CRPC. There are a number of treatments that are used for prostate cancer, either early in the disease or once it has stopped responding to standard first-line hormone treatment. We are testing these tre