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Examination Paper in Pharmacology for Students Majored in Basic Medicine (2001) score referee 1．agonist ： 2．first pass effect： 3．bioavailability： 4．steady state concentration(Css)： 5．multidrug resistance： score referee The time-concentration relationship of a drug is shown in the figure. Please judge that the drug belongs to what kind of elimination kinetics(first-order or zero-order) ? And please describe the properties of this kind of elimination kinetics. (6%) 2. Give a brife discription of the pharmacological action of Ca2+ channel blockers. (6%) 3. Give a brife discription of the mechanism of Morphine’s relieving pain action in the central nervous system. (6%) 4.Describe the molecular mechanism and clinical uses of furosemide.(6%) 5.Describe the common properties of quinolones(喹诺酮类).（6%） 6. Please discuss the whole course of a drug from its oral absorption to excretion. (10%) 7.What are the strategies for the treatment of congestine heart failure (CHF)? List the classes of drugs that can be used in CHF and give an example for each class. (10%) score referee 通常药物与受体以______、 _______、_______键方式结合时容易解离，不易产生持久作用。 药物在体内的生物转化分为两相反应，1相反应指_____、 ______、 ______反应。二相反应指_____反应。 用于人工冬眠的冬眠合剂由_______、______、 _____ 组成。 第一线的抗结核病药物包括___________、___________、___________、___________等 沙丁胺醇选择性地激动___________受体，使___________扩张，用于___________。 肝素通过与血浆中的___________结合，大大增强其与___________的亲和力，产生抗凝作用，肝素过量可产生___________。 score referee Each of the numbered items or incomplete statements in this section is followed by answers or by completions of the statement. Select the ONE lettered answer or completion that is BEST in each case. 1．下列受体中属于配体门控型离子通道的是（ ） A．α肾上腺素受体 B．β肾上腺素受体 C．M型乙酰胆碱受体 D．N型乙酰胆碱受体 E．H2型组织胺受体 2．下列仅适用于室性心律失常治疗的药物是（ ） A．奎尼丁 B．普萘洛尔 C．利多卡因 D．胺碘酮 E．维拉帕米 3．解热镇痛抗炎药（非甾体抗炎药）产生解热镇痛抗炎作用的共同机制是（ ） A．抑制抗原-抗体过敏反应 B．抑制体内前列腺素的生物合成 C．激动中枢的阿片受体 D．抑制体内的血管紧张素转化酶 E．促进糖皮质激素的释放 4．下列药物中能够阻断阿片受体的药物是（ ） A．吗啡 B．可待因 C．度冷丁