体外重组人细胞色素P450 2C9酿酒酵母表达体系构建及其基因多态性对药物相互作用影响初探.pdfVIP

194 2009 6 4 3 Chin Med Biotechnol, June 2009, Vol. 4, No. 3 DOI:10.3969/cmba.j.issn.1673-713X.2009.03.007 ·· P450 2C9 P450 2C9 CYP2C9 P450 2C9 CYP2C9 CYP3A4 P450 Saccharomyces cerevisiae 20% CYP2C9 100 CYP2C9 CYP2C9*1 PCR 10% ~ 20%[1] CYP2C9 CYP2C9*2 R144C 32 [2] CYP2C9*3 I359L