miRNA与心血管疾病治疗学.pdfVIP

· 427 · 生命的化学, 2013, 33(4): 427-432 单冬凯, 等. MiRNA 与心血管疾病治疗学 miRNA 与心血管疾病治疗学 1 1 1 1,2 * 单冬凯 ，丁雪燕 ，宋晓伟 ，荆清 1 2 ( 第二军医大学长海医院心血管内科，上海200433； 中国科学院上海生命科学研究院健康科学研究所，上海200031) 摘要：微RNA(microRNA, miRNA)是一类具有调控功能的小分子非编码RNA ，参与基因转录后的表达 调控。miRNA与心血管疾病具有密切联系，参与了心肌肥厚、心肌纤维化、心律失常、动脉粥样硬化 miRNA 等心血管疾病病理进程。以敲低和过表达技术为基础的治疗学研究方法，对探索心血管疾病中 的功能具有重要意义，更为其未来应用于临床治疗提供了参考。本文就miRNA心血管疾病治疗学研究 进展进行简要介绍。 关键词：miRNA ；心血管疾病；治疗学 Roles of microRNAs in cardiovascular diseases therapeutics 1 1 1 1,2* SHAN Dongkai , DING Xueyan , SONG Xiaowei , JING Qing 1 2 ( Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China; Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China) Abstract: MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression post- transcriptionally. Recent studies have demonstrated that miRNAs have close relationship with cardiovascular diseases. MiRNAs have been implicated in cardiac hypertrophy, myocardial fibrosis, arrhythmia, atherosclerosis and other cardiovascular pathological processes. Based on knockdown and overexpression of miRNAs, research methods for therapeutics in cardiovascular disease are significantly important for investigation of miRNAs’ function, and p