酒精水混合溶剂中壳聚糖有效生物矿化方法与研究.pdfVIP

中国科技论文在线 Rapid biomimetic mineralization of chitosan sponges with a facile method in ethanol/water mixed solution Li Lihua, Zhou Changren (Department of materials science and engineering, Jinan University, Guangzhou 510632) Abstract: Mineralization of biopolymers is a hot topic and a promising method for tissue engineering. In this study, biomimetic mineralization of chitosan sponges was performed in a large quantity with a rapid and facile approach. The calcium phosphate apatite was co-precipitated as the precursor for the formation of hydroxyapatite in mixed water-ethanol solution. The component and morphology of the apatite and the nanocomposite hybrid sponges were measured with XRD, TEM, FTIR and ESEM. The mechanism of nucleation and growth of crystals were discussed as well. Results revealed that chitosan matrix improved the crystalline quality of hydroxyapatite (HAP) crystals. With elongation of mineralization time, the mineral layers on the outer surface and inner section of chitosan sponges increased. The chitosan sponge or the microenvironment around it promoted the crystallites quality of HAP phase. Furthermore, the compressive strength and modulus of the HAP-chitosan bio-composites increased to 0.55 MPa and 29.29± 1.25 MPa respectively. Such one-pot approach might be extended to the mineralization of other biopolymers and will have a very broad application in the future. Keywords: Mineralization; Chitosan; Hydroxyapatite; Nanocomposite 0 Introduction The field of crystal growth impinges upon many disciplines, including biomineralisation, materials science and mineralogy. Natural and synthetic materials are often crystalline to some degree. The process by which a disordered sys