大鼠出生后内侧膝状体腹侧部神经元电生理和形态学特性发育变化.pdfVIP

Acta Physiologica Sinica, June 25, 2005, 57 (3): 333-339 333 * 400038 (biocytin) (postnatal day, P) 3~30 (P3~30)(ventral partition of medial geniculate body, MGBv) (1) P3~30 MGBv −40 mV −67 mV (P0.01); 1 832 M Ω 806 M Ω (P0.01); 2.55 ms 0.96 ms (P0.01) (P0.01); (2)K+ 4-AP P6 MGBv P16 Ca2+ CdCl2 P16 MGBv (3)biocytin MGBv MGBv (tufted neuron) MGB v Q426; Q424; R322.81; R338.8 Changes in electrophysiological and morphological properties of neuron in the ventral partition of medial geniculate body during the postnatal development of rats YAO Xiao-Hong, XIONG Ying* Department of Physiology, Third Military Medical University, Chongqing 400038 China Abstract: We investigated the electrophysiological and morphological characteristics of the neurons in the ventral partition of medial geniculate body (MGBv) in the rat during postnatal development (postnatal day 3~30, P3~30) with whole-cell patch clamp recording and intracellular labeling technique. The results are as follows: (1) There was an increase in the negativity of the resting membrane potential, a decrease in the input resistance and the time constant of the MGBv neurons of rats during the postnatal development; the amplitude, threshold and duration of the action potentials were also different on different postnatal days; (2) During the postnatal development, the changes in voltage-dependent ion channels dramatically influenced the waveform of action potential in the MGBv + neurons. Application of 4-AP, a K -channel blocker, reduced the amplitude and prolonged the durations of the action potentials in P6 2+ neurons, and inactivated the neurons at the end of the pulse in P16 rats. Application of