鼠李糖上清缓解酒精引起肠道破坏及肝脏损伤.pdfVIP

Am J Physiol Gastrointest Liver Physiol 303: G32–G41, 2012. First published April 26, 2012; doi:10.1152/ajpgi.00024.2012. Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury Yuhua Wang,1,2* Yanlong Liu,1,3* Anju Sidhu,1 Zhenhua Ma,1,4 Craig McClain,1,5,6,7 and Wenke Feng1,7 1 5 7 Departments of Medicine, Pharmacology and Toxicology, School of Medicine, and Alcohol Research Center, University of Louisville; 6Robley Rex Veterans Affairs Medical Center, Louisville, Kentucky; 2College of Food Science and Engineering, Jilin Agricultural University, Changchun, China; 3School of Pharmacy, Wenzhou Medical College, Wenzhou, China; 4First Hospital, Xi’an Jiaotong University, Xi’an, China Submitted 20 January 2012; accepted in ?nal form 19 April 2012 Wang Y, Liu Y, Sidhu A, Ma Z, McClain C, Feng W. Lacto- multiple ways, including altering the normal gut ?ora and bacillus rhamnosus GG culture supernatant ameliorates acute alcohol- disrupting the gut barrier function, leading to increased portal induced intestinal permeability and liver injury. Am J Physiol Gas- circulating endotoxin levels and hepatic exposure, thus further trointest Liver Physiol 303: G32–G41, 2012. First published April 26, promoting liver in?ammation and the progression to alcoholic 2012; doi:10.1152/ajpgi.00024.2012.—Endotoxemia is a contributing liver disease ALD 38 . cofactor to alcoholic liver disease ALD , and alcohol-induced in- creased intestinal permeability is one of the mechanisms of endotoxin The