氟比洛芬酯超前镇痛对颅脑手术患者细胞因子水平影响.pdfVIP

氟比洛芬酯超前镇痛对颅脑手术患者细胞因子水平的影响 陈君梁禹李文硕 摘要目的：研究氟比洛芬酯对颅脑手术患者超前镇痛效果及对围术期血清炎性细胞因子水平的影响。方法：选 择神经外科手术患者40例，ASAI一Ⅱ级，随机分为c组和F组，每组20例。采用双盲法分别于气管插管后(切皮前 15min)静脉注射氟比洛芬酯10mL(F组)或安慰剂(c组)10mL。记录术后2、24、48h的镇痛评分(VAs值)。在麻醉 开始前(T1)、手术2 含量。记录麻醉时间、术中出血量、尿量和手术输液量及瑞芬太尼和丙泊酚用量。结果：(1)术后2h和24h的vAs评 具有确切的超前镇痛作用，并能降低颅脑手术围手术期应激炎性反应。 关键词氟比洛芬镇痛细胞因子类神经外科手术白细胞介素类 of ontheLeVeIof in The Effect PreemptiVeAnalgesicFIurbiprofen Cytokine Patients Under90ingNeurosurgeⅣ CHEN Wenshuo Jun，UANGYu，U 卸叭榭m旷A，姗5fk砌魄弘死吲讥H蚴以u日D印缸以死耐流了DDD∞仇i舭 Abst陋c￡ the on in objec“Ve：Tb analgesice目’ect“ntlrbipmfenin丑ammatorycy协kimpa“ents inves垃98tepreemptive cerebral AsA cerebral were dividedinto I一Ⅱpatients surgerymndomly uIldergoingopemtion．Methods：Fbrtyunder90ing control of10mLwas 15min C，凡=20)andnurbipIDfen F，n=20)．F1urbipmfengiVen gmup(gmup group(group intmVenou8ly at beforeskinincision．ThevaluesofVASscoreswererecorded2 haIld48 weretaken h，24 h幽er叩eration．B100dsamples before fordete瑚inationofselllmlevels andIL—10 induction 2h0f ofTNF—d，IL一6 immediately ofanesthesia盯1’b躯eline)，at aftert|leendof 24h础er ofanaes山esia fI2)，immedi8tely opera