可降解椎间融合器研究进展.pdfVIP

1500 Chinese Journal of Reparative and Reconstructive Surgery, December 2010, Vol. 24, No.12 · · 可降解椎间融合器的研究进展 周春光 宋跃明 刘浩 刘立岷 李涛 龚全 曾建成 孔清泉 【摘  要】 目的 对可降解椎间融合器（Cage ）的基础研究及临床应用进展进行综述。  方法 查阅近年来国内 外可降解Cage 的相关文献，总结可降解Cage 的基础研究及临床应用方面的最新进展。  结果 基础研究显示，可降解 Cage 刚度较金属Cage 低，可有效促进椎间融合；随着融合的进行，Cage 不断降解，但降解速度与融合的发生尚不能达到 完美匹配，而且关于降解产物引起的组织反应情况尚有争议。临床应用研究显示，可降解Cage 促进椎间融合及维持椎间 高度的疗效确切，近期疗效优良，但尚缺乏远期随访结果的支持。  结论 可降解Cage 可有效促进椎间融合。 【关键词】 可降解椎间融合器 基础研究 临床应用 中图分类号： R318.08 R681.5 文献标志码：A CURRENT DEVELOPMENT OF RESEARCH OF BIODEGRADABLE INTERBODY FUSION CAGE/ZHOU Chunguang, SONG Yueming, LIU Hao, LIU Limin, LI Tao, GONG Quan, ZENG Jiancheng, KONG Qingquan. Department of Orthopedics, West China Hospital of Sichuan University, Chengdu Sichuan, 610041, P.R.China. Corresponding author: SONG Yueming, E-mail: sym_cd@ 【Abstract 】 Objective To summarize the basic research and the cl inical appl ication of biodegradable interbody fusion Cage. Methods Recent literature concerning biodegradable interbody fusion Cage at home and abroad was extensively reviewed, and current developments of the basic research and the clinical application of biodegradable interbody fusion Cage were investigated. Results Basic research showes that the stiffness of biodegradable interbody fusion Cage is lower than that of metallic Cage, so it can enhance interbody fusion. As interbody fusion proceeded, biodegradable interbody fusion Cage degrades constantly, but the speed of degradation can not keep in parallel with that of fusion. In addition, the tissue response to degradation products is controversy. Clinical application showes that the biodegradable interbody fusion Cage can enhance interbody fusion and maintain disc space height. The sho