奥美拉唑联合黛力新治疗非糜烂性胃食管反流病疗效观察.pdfVIP

·论著· 奥美拉唑联合黛力新治疗非糜烂性胃食管反流病疗效观察 杨艳果 杨小军 张少君 王琦 郑立宏 (郧阳医学院附属人民医院消化内科，湖北 十堰442000) [摘要]【目的】探讨质子泵抑制剂奥美扭唑联合黛力新治疗非糜烂性胃食管反流病(NERD)的临床疗 效。【方法】将本院2008年1月至2008年12月消化门诊及住院共82例NERD患者随机分为两组，A组41 例，给予奥美拉唑20mg，早、晚餐前备1次，黛力新10．5mg，早、中餐后各1次；B组41例，给予奥美拉唑 20mg，早、晚餐前各1次，两组疗程均为6周，疗程结束后通过症状记分，判断疗效。【结果】治疗6周后，A 组显效率为73．17％，总有效率为93．68％；B组显效率为41．46％，总有效率为75．61％。两组比较差异有 显著性(Po．05)。【结论】奥美拉唑联合黛力新是治疗伴有抑郁和(或)焦虑的NERD患者的有效方案。 [关键词] 胃食管反流／药物疗法； 奥美拉唑／投药和剂量； 抗焦虑药／投药和剂量 Clinical of inCombinationwithDeanxitfortheTreatmentofNon-Erosive EfficacyOmeprazole RefluxDiseaseYANG al Gastroesophageal Yan—guo，YANG Shao-j担，z，et Xiao-jun，ZHANG Renmin Medical 442000， (DepartmentofGastroenterology，AffiliatedHospital，YunyangCollege，Hubei 0lina) theclinical of in withDeanxitin [Abstract][Objective]Tostudy combination efficacyOmeprazole treating withnon-erosive reflux two withnon-erosive patients gastroesophageaidisease．[Methods]Eightypatients gas— refluxdiseasewere dividedintotwo one A)received troesophageal randomly groups．Fortypatients(Group beforebreakfastand afterbreakfastand Omeprazole(20mg)bidsupper respectivelyplusDeanxit(10．5mg)bid lunch one B)received beforebreakfastandlunch respectively．Fortypatients(GroupOmeprazole(20mg)bid treatmentfor6weeks，the inthetwo wasevaluatedbasedonthe respectively．After therapeuticefficacy groups were differencesbetweenthetwo ontotaleffectiverate symptomscores．[Results]Theresignificant groups AVS．75．61％in i