人端粒酶催化亚单位和c—myc蛋白在胃癌及癌前病变中的表达及意义.pdfVIP

现代肿瘤医学 2010年2月 第 18卷第2期 ·327· 人端粒酶催化亚单位和 c—myc蛋白在胃癌及癌前病变中的表达及意义 滕小春 ，刘海峰 ，王国安 ExpressionandsignificanceofhTERTproteinandC—mycproteininhumangastriccanc- erandprecancerouslesion TENG Xiao —chun ．LIU Hai—feng ，WANG Guo—an DepartmentofGeriatrics，ChongqingIronandSteelCompanyHospital，Chongqing400080，China；DepartmentofGastro—enterology， GeneralHospitalofChinesePeopledArmedPoliceForces，Bering100039，China． A【bstract】 0bjecfive：TostudytheexpressionandsignificanceofhTERTproteinandC—mycproteininhuman gastricmucousmembrancelesionsandprecancerouslesion．Methods：TheexpressionofhTERTproteinandC—myc proteinin50chronicgastritisand21gastriccarcinomawasstudiedbyusingimmunohistochemicalmethod．Results： ThepositiveexpressionofhTERT proteinand C—mycproteininhumangastriccarcinomawassingificantlyhigher thaningastricdysplasia，intestinalmetaplasiaandchronicatrophicgastritis(P0．05)．Thepositiveexpressionof hTERTproteinna de——mycproteiningastricdysplasiaWas significantlyhigherthaninintestinalmetaplasiaandchro-· nicatrophicgastritiS(P0．05)．ThepositiveexpressionofhTERTproteinandC—mycinintestinalmetaplasiaWas singificantlyhigherthanthatinchronicatrophicgastritis(P0．05)．ThepositiveexpressionofhTERTproteininpa— tientswithpositiveexpressionofC—mycproteinwassing ificnatlyhigherthanthatinthosewithoutpositiveexpression ofC—mycprotein(P0．01)．Conclusion：Bothe—mycexpressionandhteactivityoftelomerasemayplayrolesin gastriccarcinomabypromotingpahtogenesisanddevelopmentofgastriccarcinoma，andC—mycproteinexpression mayplayanimpo~antroleinactivingtelomerase． K【eywords】gastriccracinoma；e—myc；humantelomerasecatalyticsubunit Modem Oncology2010，18(02)：0327—0329 【摘要】 目的：探讨人端粒酶催化亚单位(humantelomerasecatalyticsubunit，hTERT)和 e—myc蛋白在胃癌 和胃癌前病变中的表达及意义。方法：应用免疫组织化学技术检测7l例慢性胃