冰水漱口预防乳腺癌化疗口腔溃疡的临床研究.pdfVIP

20 • 论 著 • December 2014, Vol.12, No.36 Guide of China Medicine 冰水漱口预防乳腺癌化疗口腔溃疡的临床研究 郭 满 张 浩* 李伟汉 郭宛玉 皮玉灵 （南阳市中心医院乳腺、甲状腺外科，河南南阳 473003 ） 摘要 目的 方法 【 】 探讨冰水漱口对乳腺癌化疗患者口腔溃疡的预防作用。  2012 年 6 月至2013 年 12 月期间我院收治的乳腺癌化疗患 者 258 例，随机分为短时冰水漱口组 83 例；持续冰水漱口组 67 例；空白对照组 108 例。研究 3 组患者口腔溃疡发生率及构成情况。结 果 短时冰水漱口组及持续冰水漱口组患者较空白对照组患者口腔溃疡发生率低，差异均有统计学意义（P0.05 ）；短时冰水漱口组与持续 冰水漱口组口腔溃疡发生率无明显差异（P0.05 ）。结论 乳腺癌患者化疗药物输注当天冰水漱口可有效预防化疗所致口腔溃疡，经济、有 效、患者依从性高，值得在临床推广应用。 关键词 【 】乳腺癌；化疗；口腔溃疡；冰水漱口 中图分类号：R737.9 文献标识码：B 文章编号：1671-8194（2014）36-0020-02 To Explore the Clinical Valve of ice Water Gargling on Prevention of Oral Ulcer Reduced by Chemotherapy in Breast Cancer Patients GUO Man, ZHANG Hao, LI Wei-han, GUO Wan-yu, PI Yu-ling (Department of Galactophore and Thyroid Surgery, Nanyang Central Hospital, Nanyang 473003, China) [Abstract] Objective To investigate the effect of ice water gargling on prevention of oral ulcer reduced by chemotherapy in breast cancer patients. Methods 258 cases of breast cancer patients undergoing chemotherapy in our hospital during the period from June 2012 to December 2013 , were randomly divided into short-term ice water gargling group 83 cases; continuous ice water gargling group 67 cases; blank control group, 108 cases. Research the incidence and composition of oral ulcer on three groups of patients. Results Short-term ice water gargling group and continuous ice water gargling group have a lower incidence of oral ulcer than control group, the differences were statistically significant(P 0.05); Between short-term and continuous water gargling group, the