GCS在胃癌组织中的表达及意义.pdf

-452‘ GCS在胃癌组织中的表达及意义 230001 合肥安徽医科大学附属省立医院消化内科 王俊先，张开光1。李祥春，王晓秋2，丁敏2，陈柯2 【摘要】 目的研究多药耐药蛋白葡萄糖神经酰胺合成酶(GCS)在胃癌组织中的表达。方法免疫组化法检测63 例胃癌组织及30例非癌性胃组织标本中GCS的表达情况，分析其与年龄、性别、组织学类型、分化程度、淋巴结转移的相关 别、分化程度、浸润深度、淋巴结转移均无明显相关性。结论GCS蛋白在胃癌组织中存在高表达。可能足引起胃癌原发性多 药耐药的因素之一。 【关键词】葡萄糖冲经酰胺合成酶； 胃癌；免疫组化；多药耐药 中图分类号：R735．2文献标识码：A 文章编号：1009—0460(2012)05—0452—03 and of in cancertissues Expressionsignificanceglucosylceramidesynthasegastric WANe Jun—xian，ZHANG Kai-guang，LIXiang—chun，WANGXiao—qiu，DING施几，CHENKe．Departmentof Provincial toAnhuiMedical Gastroenterology，AnhuiAffiliated 230001，China Hospital Univenity，Hefei author：ZHANG Corresponding To the of cancertissues．Methodslm- I Abstract】Objectivestudyexpressionglueosylceramidesynthase(GCS)ing∞tfie muanhistoehemiealmethodwasusedtodetectthe ofGC$in63casesof cancer expression gastric tissuesand30casesofnon—cancerous tissuesthatwerereseetedin ofAnhuiProvincialfrom 2008tO June October2008．Therelationwith gastric surgicaldepartment Hospital the node andthe ofGCSwere histologiei|ltype，differentiation，lyrephmetastasis，patientsage，sexexpression analyzed．Results The ofGCSin cancertissueswas thanthatinnon·eaneemus positive rate expression gastric hi【gher gastrictissues(49．2％∞．29．3％． P0．05)．The ofGCSwasnotrelatedwith ofinvasionand nodemetastasis expression patient’Sage，SeX，differentiation，depthlymph Becauseof an roleinintrinsicr