骨与关节化脓性感染的病原菌分布及其耐药性分析.pdfVIP

蚌埠医学院学报2014年9 月第39卷第9期 1187 [文章编号] 1000-2200(2014)09-1187-03 ·临床医学· 骨与关节化脓性感染的病原菌分布及其耐药性分析 张继学 [摘要]目的:评估骨与关节化脓性感染的主要病原菌分布及其抗菌谱变化情况,为临床抗菌药物治疗提供参考依据。 方法: 分析骨与关节化脓性感染患者的418份各类标本中分离出的病原菌,进行菌种鉴定和药敏试验。 结果:418份送检标本中共 + - 分离出388株病原菌,其中G 球菌212株,G 杆菌176株。 金黄色葡萄球菌、铜绿假单胞菌、大肠埃希菌、奇异变形菌和表皮 葡萄球菌的检出率最高,分别为38.28%、11.48%、8.13%、5.26%和4.78%。 结论:耐药的金黄色葡萄球菌是骨与关节化脓 性感染的主要致病菌,治疗应依据药敏试验结果实施个体化的抗生素治疗方案,降低细菌耐药性的发生。 [关键词]感染;化脓性;骨与关节;耐药性;病原菌 [中国图书资料分类法分类号] R631 [文献标志码]A The pathogenic bacteria distribution of bone andjoint purulent infection and its drug resistance ZHANGJi-xue (Department of Orthopedics,AnhuiProvincial Tumor Hospital,HefeiAnhui230031,China) [Abstract] Objective:To explore the pathogenic bacteria distribution of bone andjoint purulent infection and its drug resistance for providing the basis of antimicrobial treatment.Methods:The pathogenic bacteria from 418 samples of patients with bone and joint purulent infection were isolated and identified,and the antibiotics sensitivity tests were examined.Results:Two hundred and twelve strains gram-positive bacteria and 176 gram-negative bacteria were isolated form 418 samples.The detection rates of Staphylococcus aureus,Pseudomon asaeruginosa,Escherichia coli,Proteus mirabilis and Staphylococcus epidermidis were 38.28%,11.48%,8.13%, 5.26% and4.78%,respectively.Conclusions:The drug-resistant Staphylococcusaureusisthemainly pathogenicbacteriaof bone and joint purulentinfection.Theantibioticstreatmentshouldbetakenaccordingtotheresultsof antibioticssensitivitytestswhichcaninduce the resistance to antibiotics. [Key words] infection;purulency;bone andjoints;drug resistance;pathogen 应用抗生素是治疗骨与关节化脓性感染的重要