AktPKB 抗凋亡机制与天然活性物质的抗肿瘤作用.pdfVIP

第23 卷 第1 期 生命科学 Vol. 23, No. 1 20 11 年1 月 Chinese Bulletin of Life Sciences Jan., 20 11 文章编号：1004-0374(2011)01-0001-06 ·评述与综述· Akt/PKB抗凋亡机制与天然活性物质的抗肿瘤作用 1 2 1* 1 刘玉梅 ，祖桂芳 ，赵晓红 ，梅　晶 ( 1 北京联合大学应用文理学院，北京 100 19 1；2 首都师范大学生物科学学院，北京1000 37) 摘　要：Akt/PKB 是调控细胞生存与凋亡的重要信号物质之一。它能够影响下游多种效应分子的活化状 态，在细胞内发挥着抑制细胞凋亡、促进细胞增殖的作用，并同人类多种肿瘤的发生发展密切相关。 天然活性物质能够通过抑制Akt/ PKB 通路、诱导细胞凋亡来发挥它们的抗肿瘤效应。对Akt/PKB 与细 胞凋亡关系的研究不但有利于理解细胞凋亡机制，还可以指导开发新型的抗癌活性物质。本文综述了 Akt/PKB 对细胞凋亡、存活的调节机制及天然活性物质通过PI3K/Akt 信号通路抗肿瘤作用的研究进展。 关键词：A k t / P K B ；细胞凋亡；信号通路；抗肿瘤；天然活性物质 中图分类号：Q 7 1 The anti-apoptosis mechanism s of Akt/PKB and anti-tumor effect s of natural active sub stances 1 2 1 LIU Yu-Mei , ZU Gui-Fang , ZHAO Xiao-Hong *, MEI Jing (1 College of Applied Arts and Sciences, Beij ing Union University, Beij ing 100 19 1, China; 2 College of Life Science, Capital Normal University, Beij ing 100037, China) Abstract: Akt/PKB is one of the important signal molecules, which play a pivotal role in inhibiting apoptosis, promoting proliferation and influencing the activation state of some downstream molecules, and is closely correlated with human tumorigenesis. The anti-tumor effects of natural active substances can be achieved by inhibiting Akt signaling pathway to induce apoptosis. The study of the relationship between Akt/PKB and apoptosis is important, not only for understanding the basic cellular life phenomenon, but also for developing new antica