咪喹莫特不良反应的文献分析.pdfVIP

中国药物应用与监测2012年6月第9卷第3期 Chinese Journal of Drug Application and Monitoring, Vol.9, No.3, June 2012 咪喹莫特不良反应的文献分析 杨宇光，赵 华（解放军总医院皮肤科，北京 100853 ） [摘要] 通过检索1988 – 2012 年国内外文献报道的与咪喹莫特相关的不良反应病例，对患者的一般情况、用药情况、不良反 应的临床表现、预后和转归进行总结分析。咪喹莫特相关的不良反应主要表现为用药局部的红斑及其他多种皮肤损害，多发 生于用药数周后。经过停药及对症治疗，大多数患者痊愈，未出现严重不良反应。咪喹莫特可引起多种多样的皮肤症状，临 床用药过程中应注意严格用药频次和用药剂量。 [关键词] 咪喹莫特；药品不良反应；皮肤损害 [ 中图分类号] R979.5 [文献标识码] A [文章编号] 1672 – 8157(2012)03 – 0176 – 03 Adverse drug reaction of imiquimod: literatures review and analysis YANG Yu-guang, ZHAO Hua(Department of Dermatology, PLA General Hospital, Beijing 100853, China) [ABSTRACT] The case reports of adverse drug reaction related to imiquimod published in literatures from 1988 to 2012 were collected, and the baseline characteristics of the patients, the situation of drug use, the clinical manifestations, prognosis and outcome of the adverse drug reaction were analyzed. The main clinical manifestations were local erythema and other skin lesions, which often occurred several weeks after application. After drug withdrawal and heteropathy, most patients were cured. No severe adverse drug reaction was reported. Although imiquimod has favorable therapeutic efficacy, it may induce various skin lesions. More attention should be paid to the frequency and dosage of clinical application. [KEY WORDS] Imiquimod; Adverse drug reaction; Skin lesion 咪喹莫特（imiquimod ）是由3M 公司开发研制的 反应，大多可以自行消退或者经降低用药频率后缓解。 [1] [2-3] 咪唑喹啉胺类免疫应答调节药 ，1997 年最先在美国 但也有因症状较重甚至出现溃疡而中断治疗者 。 上市并成为FDA 批准的第一个外用治疗外生殖器疣 出现刺激症状的时间一般在2 周左右。咪喹莫特引起 的免疫调节药物，现已进入全球40 多个国家。本品 的局部刺激症状与其疗效呈正相关，如用药后没有红