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目 录
中文摘要 ···················································1
英文摘要 ···················································3
引 言 ····················································6
正 文 ····················································8
1.实验材料 ·················································8
1.1 实验动物及饲养条件·······································8
1.1.1 实验动物···············································8
1.1.2 动物饲养条件 ···········································8
1.2 实验药物·················································8
1.3 主要试剂及仪器 ···········································8
2. 实验方法··················································9
2.1 动物分组及干预措施 ······································10
2.2 模型制备方法 ············································10
2.3 动物模型成功的标准 ··································10
2.4 取材及组织处理 ·······································11
2.5 观测指标及方法 ··········································11
2.5.1 神经功能缺损评分 ··································11
2.5.2 脑组织病理形态学观察 ·····························11
2.5.3 免疫组织化学染色 ··································12
2.6 统计方法 ················································13
3. 实验结果·················································13
3.1 神经功能缺损评估结果 ·······························13
3.2 脑组织病理形态改变 ··································14
3.3 各组CHOP 蛋白表达的比较 ·····························15
3.4 各组Gadd34 蛋白表达的比较 ···························17
4.讨 论 ················································18
5.存在的问题和展望 ······································35
结 论 ··················································37
参考文献 ··················································38
附 录 ··················································49
综 述 ··················································53
致 谢 ··················································66
攻读学位期间发表的学术论文目录 ·······················67
作者声明 ··················································68
个人简历 ·································
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