高一致性药物诱导体外细胞毒作用一种新细胞为基础模式使用高含量测定筛选人肝.pdfVIP

Arch Toxicol (2006) 80: 580–604 DOI 10.1007/s00204-006-0091-3 ORGAN TOXICITY AND MECHANISMS P. J. O’Brien Æ W. Irwin Æ D. Diaz Æ E. Howard-Cofield C. M. Krejsa Æ M. R. Slaughter Æ B. Gao N. Kaludercic Æ A. Angeline Æ P. Bernardi P. Brain Æ C. Hougham High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening Received: 30 April 2005 / Accepted: 1 March 2006 / Published online: 6 April 2006 Springer-Verlag 2006 Abstract To develop and validate a practical, in vitro, gan toxicitie