大规模基因组测序中的信息分析.pptVIP

大规模基因组测序中的信息分析--拼接与注释 大规模测序是基因组研究的最基本任务，它的每一个环节都与信息分析紧密相关。从测序仪的光密度采样与分析、碱基读出、载体标识与去除、拼接与组装、填补序列间隙、到重复序列标识、读框预测和基因标注的每一步都是紧密依赖基因组信息学的软件和数据库的。  How to find the coding regions in  rude DNA sequence? Statistical method and Sequence Alignment Method eneven positional base frequence (D value) Neural network predicting the splicing sites Fractal dimension of exons and introns Complexity analysis How many different patterns are there in the area of the different DNA sequence? Method and Techniques in Cryptology Coincident Indexs Unicity Distance ＃ Hidden-Markov method(HMM) Glimmerv Neural network method A improved back-propagation (BP) learning algorithm have been built in the study. One goal of this network is to find the splicing site between intron and exon. Neural Network Procedure Fractal dimension of exon and intron We introduce the mapping from nucleotide sequences to two-dimensional metric space by assigning each nucleotide a fixed vector and constructing a representation by joining these vectors end-to-end. Fractal Dimension of Exon and Intron Sequences Complexity analysis In our case complexity means that how many patterns of base connections are there in a window, which are from different parts of DNA sequences. Our results show that the complexity of exon is larger than the complexity of intron and 5’-flanking and 3’-flanking. Relative Complexity in Exon, Intron and Flanks Using the methods and techniques in cryptology One could think that the DNA sequences are similar with the telegram, which has been used to transmit secrets in the field of commerce or military affairs, so we try to apply methods and techniques in cryptology to DNA sequence analysis. As the first step we introduce some parameters of cryptology to DNA sequence analysis. Coincident index In cryptology this parameter has been used to find the plain c