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Caffeine, the stimulant incoffee,has been called
“the most widely usedpsychoactive substance on Earth.”
Synder, Daly and Bruns have recently proposed that
caffeine affects behavior bycounteringthe activity in
(5)
(5)
((55))the human brain of a naturally occurringchemical called
adenosine. Adenosine normally depresses neuron firing
inmany areas of the brain. It apparently does this by 腺苷受体通过结合特定神经元膜
inhibiting the release of neurotransmitters, chemicals 抑制神经元射击,从而抑制神经
that carrynerve impulses from one neuron tothe next. 传递物的释放
(10)
(10)
((1100))Like many other agents that affect neuron firing,
adenosine must first bind tospecific receptors on
neuronal membranes. There are at least two classes
of these receptors, which have been designated A1 and
A2. Snyder et al propose that caffeine, which is struc- 说明咖啡因和腺苷之间的结
(15)
(15)
((1155))turally similar toadenosine, is able tobind tobothtypes 构关系是原因之一。
of receptors, which prevents adenosine from attaching
there and allows the neurons tofire more readily than
theyotherwise would.
For many years, caffeine’seffects have beenattri-
(20)
(20)
((2200))buted toits inhibition of the production ofphosphodi-
esterase, an enzyme that breaks downthe chemical 说明了phosphodiesterase的作用
Esterase
called cyclic AMP.A number of neurotransmitters exert
their effects byfirst increas
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