MTDH在三阴性乳腺癌中的表达及与一线化疗的关系.pdfVIP

现代肿瘤医学 2014年6月 第22卷第6期 MODERN ONCOLOGY，Jun.2014，VOL.22，NO.06 ·1315 · MTDH在三阴性乳腺癌中的表达及与一线化疗的关系 尤振宇，刘 洋 ＭＴＤＨ ｅｘｐｒｅｓｓｉｏｎ ｉｎ ｔｒｉｐｌｅ ｎｅｇａｔｉｖｅ ｂｒｅａｓｔ ｃａｎｃｅｒ ａｎｄ ｉｔｓ ａｓｓｏｃｉａｔｉｏｎ ｗｉｔｈ ｆｉｒｓｔ ｌｉｎｅ ｃｈｅｍｏ- ｔｈｅｒａｐｙ You Zhenyu，Liu Yang Department of Oncology，202 Hospital of the PLA，Liaoning Shenyang 110003，hina. 【Abstract】 Objective：To detect the expression of MTDH in tumor tissues of patients with triple negative breast cancer and to investigate its association with first line chemotherapy.Methods：MTDHwas detected in the tumor tis- sues of 124 patients diagnosed with triple negative breast cancer TNBC）by immunohistochemistry.The relationship between MTDH expression level and clinical characteristics of TNBC patients were analyzed.45 patients with ad- vanced diseasewere treated with first -line chemotherapy and were followed up for 36 months.The relationship of MTDH expressiontochemotherapeuticefficacy andprogressionfree survivalwasexplored.Results：MTDHwashighly expressed in the tumor tissues of TNBCpatients.MTDH expression is correlated with nodal metastasis P ＝0.005）， tumor stage P＝0.001），distant metastasis P ＝0.001）and Ki67 index P ＝0.041）. Of the45 advanced patients treatedwith first-line chemotherapy，high MTDH expression predicted a poor responsive rate 32.1％ vs64.7％，P ＝0.033）and a short progression free survival 4.0 vs 11.0 months，P ＝0.031）.Conclusion：High MTDH expres- sion in TNBCcorrelateswithnodal metastasis，advancedstage，distant metastasisandhigh Ki67 index；MTDHexpres- sion islikelytobecomeapredictiveandprognosticfactorforadvancedTNBCpatientswhoreceivedfirst-linechemo- therapy. 【Key words】triple negative breast cancer；MTDH；immunohisochemistry；chemotherapy；progression free survival Modern Oncology2014，22 06）：1315-1318 【摘要】 目的：探讨三阴性乳腺