男性不育发病原因的研究进展.pdfVIP

M od D iagn Treat 2006 J ly 17 4 # 227# 姚文亮, 吴飞华 , 330006 Research Progress in Pathogenic Factors ofM ale Infertility YAO W en- liang, WU Fe-i h a J iangx i College of Traditional ChineseM edicine, Nanchang 330006, China Abs tract: Pathogenic factors ofmale infertility arem any. According to the d iagnostic standard ofmale infertility w hich is p t forw ard byWHO, the recent progress in research on pathogen ic ca ses ofm ale infertility is ana- lyzed and s mmarized. K ey w ord s: M ale infertility; Pathogen ic factors : , WHO, : ; : R711. 6 : A : 1001-8174 2006 04-0227-02 [ 1] WHO , 1, AsAb, AsAb , , : 10% , 20% ~ 25% , , [5] , , , [ 6] , Sak in-Kaindl WHO , , Ant-i , body-dependent cell clar cytotoxicity, ADCC , [ 7] 11: 1 ; 2 Korotkova A sAb [ 8] ; 3 ; 4 ; 5 , M yogo AsAb ; 6 ; 7 ; 8 Acrosom e response, AR [ 9] + + ; 9 ; 10 ; 11 N i A sAb Na -K -ATP + + , Na -K -ATP 1 3 : 1 ; 2 ; 3 , ; 4 , Azoosperm ia factor, AZF [ 10] , AZFa , 75% , Sertoli, 25% , ; [ 2] AZFb, ; AZFc AZFd , , , H owy 2 Ja-cobs, POLG Antisperm antibody, AsAb , , , [ 11] [ 12] , , , [ 3] [ 13] , Progesterone receptor, PR [ 4] , AsAb , PR , Yq11, 23 # 228# M od D iagn Treat 2006 J ly 17 4 , , , , , Y YRRM2YRRM 1YRRM 2DAZ 8 [ 14] [ 15] DFFRYDBY , , 4 , [26] , , [ 16] , , , , , [ 17] 9 , , , , , , N0 60 H SP60 [ 27] , 90% , [ 18] 10 , 12% 5 , , , , , , , , , , , , 6 , [ 28] [29] , [ 19] , [ 20] [30] [ 31] , 25% , [ 32] , , 11 [ 21] C [ 22] [ 33] DNA B , 12 DNA , , , [ 34] A , M orales [ 23] , , , A 10, , A , , ! , A : , E [ 1], . [M ].: . 2004. 934. , [ 24] [ 2] . [ J]. : , 1985, 3: 5. , [ 3]M arshb rn PB, K tteh WH. The role of antisperm antibodies in infertility 7 [ J]. Fertil Steril, 1994, 61 5 : 799-811. , [ 4] Soffer Y. Male genitalm ycoplasm as and chlam ydia trachom atis c lt re: its [ 25] K linefdter relationship w ith accessory gland f nction, sperm q ality and a tomi m n-i , ty[ J]. Ferti