药物效应动力学陈季强.pptVIP

Chapter 2. Pharmacokinetics (1)To explain the drug action and mechanisms of drug action, and to direct clinical administration; (1)Preclinical pharmacology: ●The object of research: Human being; (1)Source of new drugs: ●Preclinical study(临床前研究) : ▲ Phase Ⅰ(一期临床): 20-30位健康志愿者; Chapter 1. Pharmacodynamics Part 1. Basic action of drug Part 2. Dose-effect relationship Part 3. Mechanism of drug action Part 4. Drug and Receptor 1. Action and effect of drug: (1)Concept of action and effect: ①Action: e.g.: Noradrenaline(NA) stimulat-ing ? receptor of blood vessel ? ②Effect: ▲ Vasoconstriction and BP ?; ▲ After BP ?, reflex heart rate ?. ①Definition of selectivity; (1)Therapeutic effect: ①Side reaction(副作用); (2)Adverse drug reaction(ADR): ①Side reaction(副作用);  ①Side reaction(副作用); Let’s take a rest (2)Response (effect): ①Graded response (量反应) (3)Dose effect curve: ①Dose-effect curve: (D, C) ②Dose-effect curve (logD or logC) ③Dose-effect curve(logD or logC) ● Dose-effect relationships ED50: 50% effective dose     Therapeutic index(TI) = LD50 / ED50 Margin of safety: ED95~LD5 or ED99~LD1 E A B A’ B’ 　 Part 3. Mechanism of Drug action 1. Action on receptor; 2. Interfering cell metabolism; 3. Influencing transportation; 4. Action on enzyme