替莫唑胺治疗复发性胶质瘤的疗效分析_晏怡.pdfVIP

20 10 37 1 ·9 1 · DOI:10.3 971/j.issn.100 0-857 8.2 010.01.025 1 1 2 晏　怡, 唐文渊, 邓朝霞 Efficacy of Temozolomide in Treatment of Recurrent Glioma 1 1 2 YA N Yi , TA NG W en-yuan , DENG Zhao-xia 1.Dep artment of Neurosurgery, The F irst Af f iliated Hosp ital of Chongqing Medical University, Chongqing 400 016, China;2.Dep artment of Intensive Care Unit, X inan Hosp ital of The Third Mili- tary Medical University Abstract:Objective 　T o evaluate the efficacy of T emozolomide in the treatment of recurrent lioma. Methods　Thirty-five patients with recurrent lioma were enrolled in our study .Accordin to the history of temozolomide administration, 35 patients were divided into roup F (the patients first treated with te- mozolomide), roup R (the patients re-treated w ith temozolomide), and roup N (the patients without chemotherapeutic history).Clinical evaluations and assessments of tumor response w ere performed every 2 months.Results　In roup F, the complete response(CR)was not observed, partial response (P R)in 6 cases, stable disease(SD)in 10 cases, and 5 cases developed pro ressive disease(P D).In roup R, the complete response(CR)w as not observed, partial response (PR)w as observed in 2 cases, stable disease (SD)in 4 cases, and 9 cases developed pro ressive disease(PD).In roup N, the complete response(C R) was not observed, partial response (PR)w as observed in 1 cases, stable disease(SD)in 5 cases, and 9 cases developed pro ressive disease(PD).Therein, (P R+SD )in roup F was si nificantly hi her than roup R and roup N respectively (both 0.05 ).Cases of 6 month overall survival in roup F w as more than those in roup R (0.0 5)and roup N (0.0 1).Conclusion　Initial use of temozolomide is effective for recurrent lioma, but the curative effectiveness of temozolomide re-administration is not o