平性药桃仁对瘀热互结证大鼠模型的影响.pdfVIP

第十一届中南地区实验动物科技交流会论文集 平性药桃仁对瘀热互结证大鼠模型的影响 郝二伟，杜正彩，包传红，芦晓燕，唐志玲，邓秀琼 （广西中医学院 南宁 530001 ） 【摘要】目的 通过观察平性药桃仁对瘀热互结证模型大鼠各项指标的影响，初步探讨 平性药的作用特征。方法 采用注射活性酵母菌及角叉菜胶相结合的方法复制瘀热互结证大 鼠模型，用平性药桃仁进行干预，同时以寒性药益母草、温性药川芎为对照，观察各组大鼠 体征、血液流变学各项指标的变化。结果 与正常组比较，模型组大鼠出现明显的“瘀热”体 征，全血粘度等血液流变学各项指标明显异常。平性药桃仁组与模型组相比较，能明显改善 瘀热互结证大鼠的“瘀热”体征，改善血液流变学（全血高、中、低切粘度值、红细胞变形指 数、红细胞压积、红细胞电泳时间、卡松屈服应力等）各项指标。结论 平性药桃仁能明显 改善瘀热互结证大鼠“瘀热”体征、血液流变学各项指标，作用于瘀热互结证时表现出类似寒 性药的作用特征。 【关键词】平性药；桃仁；瘀热互结证 The Influence of Peach Kernel with Neutral Property on the Model Rats with Blood Stasis and Heat Accumulation Syndrome 1 2 1 1 DENG Jia-gang , HAO Er-wei , DU Zheng-cai , BAO Chuan-hong , 1 1 1 LU Xiao-yan , TANG Zhi-ling , DENG Xiu-qiong （1 Guangxi Traditional Chinese Medicine University, Nanning, 530001； 2 Shandong Traditional Chinese Medicine University, Jinan, 250355 ） 【Obstract 】 Objective: To investigate the characteristics of the neutral property Chinese drugs, by observing the influence of Peach kernel on the indicators in model rats with blood stasis and heat accumulation syndrome. Methods: The rat models with blood stasis and heat accumulation syndrome were developed by injecting yeast in combination with carrageenan(Ca), and given Peach Kernel with neutral property, rizome of Chuanxiong Ligusticum with hot property, radix paeoniae rubra with cool property, and physical signs in rats and blood rheology parameters were observed. Results: Compared with the normal group, the rats of Model group showed obvious signs of blood stasis and hot syndromes, the indicators of blood rheology parameters were significantly