激光治疗黄褐斑安全性和有效性分析.docVIP

激光治疗黄褐斑的安全性与有效性分析 [摘要] 目的研究Q开关lO64 nm激光治疗黄褐斑的安全性与有效性。方法临床入选67例脸部黄褐斑患者，均采用大光斑低能量调Q开关Nd：YAG 1064 nm激光治疗，治疗1次／w，疗程为10—20 W，治疗后加以内调阿胶黄精丸进行调理。最后分析该治疗方法的安全性与有效性。结果皮损区域治疗后的皮肤点黑色素指数较治疗前明显降低(P0．05)，而颈部正常皮肤的皮肤点黑色素指数在治疗前后无统计学差异(P0．05)；皮损区域治疗后的经皮肤水分丢失量较治疗前明显增高(P0．05)，而颈部正常皮肤的经皮肤水分丢失量在治疗前后无统计学差异(P0．05)；对于最后疗效，医师评价的总有效率为92．54％ ，患者的总满意度为86．57％ 。在治疗过程中，有15例(22．39％)患者出现了轻微的皮肤烧灼感、紧缩感及干燥感等不良反应。结论大光斑低能量调Q开关Nd：YAG 1064 nm激光联合内调的阿胶黄精丸治疗黄褐斑安全有效。 Safety and eficacy of laser therapy of chloasma Wang Sha，Chen Xiaoqiang Department of Dermatology，Hospital 161 of PLA，Wuhan，Hubei，430000，China [Abstract] 0bjective To investigate the safety and efficacy of Q switch 1，064 nm laser in the treatment of chloasma． Methods Sixty seven patients with chloasma were selected to receive the treatment by great spot low energy Q switch Nd：YAG l，064 nm laser once a week for 10—2O W．After the treatment．the safety and eficacy of this method were analyzed．Results Compa~d with the melanin index before the treatment，that of the skin in the lesion areas significantly decreased(P0．05)，but there was no significant difference between this index in the normal eervieal skin before and after the treatment(P0．05)．The transepidermal water loss of the lesion areas significantly increased after the treatment，but there Was no significantly difference between in the norm al cervical skin before and after the treatment(P0．05)．The total effective rate evalu~ed by the physicians was 92．54％ 。and the total satisfaction of the patients Was 86．57％ ．During the treatment，adverse reactions occurred in 15 cases(22．39％ )，such as mild burning sensation of the skin，tightness，and dry sensation，etc．Conclusion Great spot low energy Q switch Nd：YAG l，064 nm laser iS safe and effective for the treatment of chloasma． [Key words] chloasma；laser；safety；eficacy 黄褐斑是一种常见的面部色素增加性皮肤病，在中青年女性中多见，多数没有明显症状，一般表现为色素沉着呈蝶状分布，轻者为淡黄色或浅褐色呈散在分布，多见于眼部下外侧；重者表现为深褐色或浅黑色密布于整个面部¨ 。过去主要采用外用去色素、脱色素制剂、化学剥脱剂等常规治疗，但其疗效尚不令人满意，容易产生炎症后色素沉着、色素不均以及接触性皮炎等并发症。随着医学诊疗技术的不断发展，激光及强脉冲光技术