mPEG-DSPE修饰的紫杉醇脂质体的制备及其药动学研究.pdfVIP

mPEG-DSPE修饰的紫杉醇脂质体的制备及其药动学研究 张自强1．一，覃斌1，李战1”，瑚b静2+(1．南京长澳医药科技有限公司，南京210022；2．中国药科大学，南京210009) 摘要：目的采用甲氧基聚乙二醇磷脂酰乙醇胺(mPEG．DSPE)修饰紫杉醇脂质体，并考察其在大鼠体内的药动学行为。方法 后脂质体的tl／2a分别为1．48和10．48 长循环特性，并可提高其体内的利用度。 关键词：甲氧基聚乙二醇磷脂酰乙醇胺；脂质体；药动学；紫杉醇 中图分类号：R944 文献标识码：A 文章编号：1001—2494(2008)03—0199—04 ofPaclitaxel ModmedwithmPEG-DSPEandItsPharmacoklneticsinRats Preparation Liposomes ZHANG PharmaceuticalScienceⅡnd Limited Binl，LIZhanl一，YAO Changao Technology Zi．qian917，QIN Jin92‘(1．Nanfing Pharmaceutical 210022，China；2．China 210009，China) Company，Nanfing University，Nanjing To the modifiedwithmPEG-DSPEand its inrats． ABSTRACT：OBJECTIVE liposomes studypharmaeokinetics preparepaclitaxel METHODSThe was andusedto the membrane．The were mPEG2000-DSPE modify paclitaxelliposomes synthesized lipid prepared was HPLC athin-film method．Theconcentrationofthe inrat determinedmethod．RESULTS by dispersion paclitaxelplasma by The sizeofthe its paelitaxellipesomesWas(411．84-31．9)am，andencapsulationWas(82．474-2．15)％．Pharma— particle resulting of were AUCvalueof cokineticshowedthat and 1．48and10．48 study tl／2B paelitaxelinjectionpaclitaxelliposomes h，respectively．The of after ofthe the Wasirlcreased．TheAUC W883．13timesasthatobtainedi．V．administration liposomes liposemes paelitaxelinjection． CONCLUSIONTheinvivo