人血浆中阿比朵尔的HPLC法测定及其药物动力学研究.pdfVIP

JournalofPharmaceuticals ·359· 中国医药工业杂志Chinese 2008。39(5) 人血浆中阿比朵尔的HPLC法测定及其药物动力学研究 杨汉煜1，张淑慧2，冯小龙1 (1．石药集团药物研究院；2．河北省人民医院药学部，河北石家庄050051) 摘要：建立HPLC法测定人血浆中阿比朵尔的含量，并研究20名健康男性志愿者口服200mg盐酸阿比朵尔胶囊后的药物动 力学。血浆样品经液．液萃取后测定，采用C。色谱柱，以磷酸盐缓冲液．甲醇(38：62)为流动相，检测波长为315nm。阿比 关键词：阿比朵尔；高效液相色谱；药物动力学；测定 中图分类号：TQ460．7+2；R969文献标识码：A 文章编号：1001—8255(2008)05-0359—03 inHumanPlasmaHPLCandIts DeterminationofArbidol by YANG Han—yul，ZHANGShu—hui2，FENG Xiao．10n91 ResearchInstitute Pharmaceutical (J．Pharmaceutical Co．，工以， ofShijiazhuang Group 2．Dept．ofPharmacy,PeoplesofHebeiProvince,Shoiazhuang050051) Hospital ABSTRACT：AHPLCmethodforthedeterminationofarbidolinhuman was plasma of20male volunteersafteroraladministrationof arbidol was pharmacokineticshealthy 200mg hydrochloridecapsules were extraction．Acolumnwas themobileof investigated．Plasmasamplespreparedbyliquid·liquid C4 used，with phase buffer thedetection of315nm．Thecalibrationcurvewaslinearin solution-methanol(38：62)，at phosphate wavelength theconcentrationof1 0-1 lowlimitof wasl RSDsofinter-and range 000lag／L．The quantificationOlag／L．The intra—day than main werelower5．2％．The wereas pharmacokineticparameters (11．8+5．0)h，AUCo-t(2641士1024)lag—hL一，AUCo．。(2751士1198)lag—hL～． KeyWords：arbidol；HPLC；pharmacokinetics；determination 盐酸阿比朵尔(a