早期应用血管加压素对非控制出血性休克大鼠器官血流灌注及功能的影响.pdfVIP

*( 400042) (arginine vasopressin AVP) 96 SD () AVP (AVP 5×10−4 U·mL− 1) () AVP (50 mmHg 3 h) AVP AVP AST ALT AVP 2 (BUN Scr) AVP AVP R965.2 A 1007-7693(2015)01-0001-04 DOI: 10.13748/ki.issn1007-7693.2015.01.001 Effects of Early Administration of Arginine Vasopressin on Blood Perfusion and Organ Function of Uncontrolled Hemorrhagic Shock Rats * YANG Guangming, LI Tao, XU Jing, TIAN Kunlun, PENG Xiaoyong, CHEN Xiangyun, LIU Liangming (State Key Laboratory of Trauma, Burns and Combined Injury, Department 2 Research Institute of Surgery, Daping Hospital, the Third Military Medical University, Chongqing 400042, China) ABSTRACT: OBJECTIVE To investigate the effects of early administration of arginine vasopressin(AVP) on blood perfusion and organ function of uncontrolled hemorrhagic shock rats. METHODS Ninety-six SD rats were divided into AVP group (5×10−4 U·mL− 1 AVP with hypotensive resuscitation) and control group(hypotensive resuscitation). Uncontrolled hemorrhagic shock model was adopted, the effects of early administration (to mimic the pre-hospital treatment period) of AVP to maintain the blood pressure (50 mmHg, 3 h) on cardiac function, blood perfusion, vital organ and mitochondrial function were observed. RESULTS Early application of AVP significantly improved the cardiac function, increased cardiac output and oxygen delivery and oxygen utilization, improved hepatic blood flow, protected th