海南萝芙木根水溶性物质急性毒性实验研究.pdfVIP

L ISH IZHEN M ED IC INE AND M AT ER IA M ED ICA RE SEA RCH 20 11 VO L . 22 NO. 4 2011 22 4 * 刘平怀, 刘洋洋 , 时 杰, 杨 勋, 李晓亮 (, , 570228) : 观察海南萝芙木根水溶性物质的急性毒性 分别采用尾静脉注射和经口灌胃进行给药实验观察实验 小鼠对海南萝芙木根水溶性物质的急性毒性表现 尾静脉注射过量的海南萝芙木根水溶性物质后小鼠会出现一 定的中毒现象, 其半数致死量 LD50 = 294. 2 mg / kg而采用灌胃给药方式毒性较小, 其最大耐受量为 3 445 mg / kg 海南萝芙木根水溶性物质口服给药不发生急性毒性反应 : 海南萝芙木; 急性毒性; 水溶性物质 DO I: do:i 10. 3969 / . issn. 10080 805. 20 11. 04. 038 : R285. 5 : A : 2011) Study on theAcuteToxicity ofW ater- Soluble Substance from Roots ofR auvofl ia ver ticil la ta Lour. Baill. Var. ha inanensis Tsiang * L IU P inghuai, L IU Y angyang , SH I J ie, YANG X un, L I X iaoliang (K ey Laboratory of App lication Technology of Hainan Sup eriorResourcesChem icalMaterials of M inistry of Edu cation, College of Materials and ChemicalEngineering, Hainan niversity, Haikou 570228, China) Abstract: Objecti e T o observe the acute tox ic ity of w ate r- so luble substance from roo ts o f Rauvoflia verticillata Lour. Ba il.l V ar. hainanensis T s iang. M ethods R esearch on acute tox icity of the w ater- so luble substance v ia intravenou s in ec tion and intra gastr ic in ection in m ice w ere ca rried out. R esults T he m ice show ed a little tox ic ity a fter intravenous in ection of the w ate r- so lu b le substance, LD = 294. 2 m g / kg. But no tox ic ity for the intragastric in ection g roup, and its m ax mi um to lera ted dose w as 3445 50 m g / kg. Conclusion In in tragastr ic in ection, the w a ter- so lub le substance from R oots o fRauvofl ia verticillata Lour. Ba il.l V a r. hainanensis T siang show ed no sign of tox ic ity in m ice. K ey words:Rauvofl ia verticillata Lour. Ba ill. V ar. haina