关于结合分枝杆菌与麻风分枝杆菌转移到骨髓细胞的研究.pdfVIP

M. tuberculosis and M. leprae Translocate from the Phagolysosome to the Cytosol in Myeloid Cells Nicole van der Wel,1,4 David Hava,2 Diane Houben,1 Donna Fluitsma,3 Maaike van Zon,1 Jason Pierson,1 Michael Brenner,2 and Peter J. Peters1,* 1The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands 2 Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA 3 VU Medical Centre, Department of Molecular Cell Biology and Immunology, Amsterdam, the Netherlands 4 Present address: VU Medical Centre, Department of Medical Microbiology and Infection Control, Amsterdam, The Netherlands. *Correspondence: p.peters@nki.nl DOI 10.1016/j.cell.2007.05.059 SUMMARY antigens that may elicit MHC- or CD1-restricted T cell responses. M. tuberculosis and M. leprae are considered to Intracellular pathogens commonly avoid lysosomal fu- be prototypical intracellular pathogens that sion through the manipulation of host signal transduction have evolved strategies to enable growth in the pathways and the alteration of endocytic traffic resulting intracellular phagosomes. In contrast, we show in privileged replicative niches. In contrast, Listeria mono- that lysosomes rapidly fuse with the virulent M. cytogenes and Shigella flexneri lyse the phagosomal mem- brane and escape from the endocytic system into the host tuberculosis- and M. leprae-containing phago- cytosol, where they replicate and are able to spread to somes of human monocyte-derived dendritic neighboring ce