GDNF及其受体Ret在腺样囊性癌嗜神经侵袭和细胞增殖中作用的初步研究.pdfVIP

380 Journal of Oral Science Research,Jun. 2010,Vol. 26, No. 3 GDNF Ret 1 2 1 1 1* 郑善川 梁丽 张玉茹 朱晓虹 李宏捷 ( 1. 天津医科大学口腔医院病理科 天津 300070; 2. 中国人民解放 302 医院病理科) [ ] : GDNF Ret ( SACC) : S- P 42 SACC5 5 GDNF Ret : GDNF SACC , Ret SACC , , Ki- 67 SACC , Ki- 67 , GDNF Ret ( r 0. 489,P 0. 05) , GDNF Ki- 67 ( r 0. 278, P 0.05) : GDNF Ret SACC , GDNF , SACC GDNF , GDNF Ret SACC , SACC GDNF [ ] (GDNF) Ret Ki- 67 [ ] R780. 2 [ ] A [ ] 1671 7651(2010) 03 0380 04 Preliminary Study in Roles of GDNF and Ret in Perineural Invasion and Prolif eration of Salivary Adenoid Cystic Carci noma. ZH ENG Shan- chuan, LIA NG L i, ZH A NG Yu- ru, et al. Dep artment of Oral P athology , ollege of Stomatology, Tianj in Medical Univ ersity , Tianj in 300070 [ Abstract] Ob ective: To invest igate the roles of GDNF and Ret in perineural invasion and proliferat ion of salivary adenoid cystic carcinoma( SACC) . Methods: T otally 42 SACC specimens, 5 acinic cell carcinoma specimens, 5 nor mal salivary tissues were included in the present study. S- P method w as used to detect the expression of GDNF and Ret in SACC specimens, acinic cell carcinoma specimens, normal salivary tissues. Results: GDNF and its receptor Ret were highly expressed in SACC cells and normal ductual cells, and GDNF w as also expressed in nerves adjacent SACC. The positive expression rates of GDNF, Ret in SACC w ere both 69. 05% ( 29/ 42) , while there was no ex pression in acinic cell carcinoma specimens and normal salivary acinus. Ki- 67 w as posit ively expressed in cytoplasm of SACC, with no statistical significance near and far from nerves, in PNI group and non- PNI group. Expression of Ret b