夏连垂盆汤论文：夏连垂盆汤治疗甲亢伴肝功能异常临床研究.docVIP

夏连垂盆汤论文：夏连垂盆汤治疗甲亢伴肝功能异常临床研究 【中文摘要】通过与单纯西药治疗方案的对比研究,客观评价中药夏连垂盆汤治疗甲亢伴肝功能异常肝火旺盛证的疗效和安全性。方法：根据随机、对照的临床观察原则,将符合甲亢伴肝功能异常,中医辨证符合肝火旺盛证诊断标准的56例病人,随机分为2组,在西药常规治疗的基础上,治疗组28例加用中药夏连垂盆汤水煎剂每日一剂。疗程为8周。治疗前后两组分别评价其临床症状、体征的变化,治疗前后观测甲状腺激素及相关抗体水平、肝功能、肝纤维化指标、心率等,以及患者的不良反应、依从性。全部数据以SPSS16.0统计软件进行统计学分析。结果：确诊并纳入的甲亢伴肝功能异常肝火旺盛证患者56例(治疗组28例,对照组28例),治疗前两组的性别、年龄等基线数据经统计学处理无显著性差异,有可比性(p0.05)。①对症状体征的改善作用：治疗组患者治疗后症状有明显改善,总有效率为96.42%；对照组总有效率75.00%。治疗组多项中医症状改善情况优于对照组(P0.05)。③甲状腺激素水平：甲状腺激素水平治疗前后比较,两组TT3、TT4、FT3、FT4均有不同程度的改善(P0.05)；治疗组TT3、TT4、FT3、FT4均明显降低,其中FT3、FT4与治疗前比较均有显著性差异(P0.05)。④甲状腺相关抗体水平与治疗前相比,治疗组TGAb、TMAb、TRAb均不同程度降低,差异有统计学意义(P0.05),两组间差异无统计学意义(P0.05)。⑥心率：治疗前后两组心率均有不同程度的改善,差异有统计学意义(P0.05)；组间比较,治疗组心率下降幅度优于对照组,差异有统计学意义(P0.05)。⑦安全性：在本研究中,治疗组与对照组均有良好的安全性,两组比较差异无明显统计学意义。结论：应用夏连垂盆汤的治疗组在改善患者自觉症状方面效果明显优于对照组；治疗组肝功能、甲状腺功能的改善幅度优于对照组；中药治疗具有调节异常的甲状腺相关抗体(TGAb、TMAb、TRAb)的作用,具有免疫调节功能,对提高甲亢疗效、缩短病程,降低复发率有一定的意义。夏连垂盆汤安全、有效,无副作用。 【英文摘要】Purpose:Treatment with control group comparative study of the program, the objective evaluation of traditional Chinese medicine treatment XiaLianChuiPeng prescription of the efficacy and safety.Methods:Based on simple random,controlled clinical trial principles, in line with the 56 cases selected Hyperthyroidism diagnosis with abnormal liver function tests,as well as the TCM Prosperity of hepatic fire standards in line with the patients.56 cases were andomly divided into two groups. On the basic of normal treatment and modern medicine,the patients of treated group (n=28) were treated by Chinese medicine while the patients of controlled group (n=28) were not. Course are for 8 weeks.The observed indexes included both curative effect indexes,such as clinic symptoms, TH level, thyroid-associated antibodies,Liver function, hepatic fibrosis index,heart rates,and safety indexes,such as routine urine,blood and stool test,ECG,the function of kidney and harmful reaction.The complete data carries on statistics analysis by the SPSS 16.0 statistics software.Results:Prior treatment,the gender,age