Wnt-1, beta-catenin 及C-myc 在上皮性卵巢癌中的表达及意义.docVIP

Wnt-1,beta-catenin及C-myc在上皮性卵巢癌中的表达及意义 胡琢瑛1，林晓2 （1重庆医科大学附属第一医院妇产科 2重庆医科大学病理科 重庆 400016） 摘要：目的 探讨Wnt-1,beta-catenin及C-myc在正常卵巢及卵巢恶性上皮肿瘤中的表达及其与临床病理特征的关系。方法 运用免疫组织化学SP法检测18例正常卵巢组织及34例卵巢恶性上皮肿瘤中Wnt-1,beta-catenin及C-myc的蛋白表达。结果 18例正常卵巢中Wnt-1、C-myc阳性表达率为5.56%、16.67%，beta-catenin异常表达率为16.67%；34例卵巢恶性上皮肿瘤Wnt-1阳性表达率为94.11%,C-myc阳性表达率及beta-catenin异常表达率为100%。卵巢恶性上皮肿瘤Wnt-1、C-myc阳性率及beta-catenin异常表达率明显高于正常卵巢成熟细胞（P＜0.05），且Wnt-1、beta-catenin及C-myc三者之间均存在显著正相关（P＜0.05）。不同类型的恶性上皮肿瘤中，只有beta-catenin及C-myc在浆液性与粘液性肿瘤中的表达有显著差异（P＜0.05）。Wnt-1、beta-catenin及C-myc与肿瘤有无浸润无关（P＞0.05）。结论 Wnt信号传导通路中Wnt-1、beta-catenin及C-myc的改变与卵巢上皮肿瘤的恶化有关，而与肿瘤的浸润无明显相关。 关键词：Wnt-1蛋白；beta-catenin；C-myc蛋白；卵巢恶性上皮肿瘤 中图法分类号：R737.31 文献标识码：A The expression of Wnt-1, Beta-catenin and C-myc in ovarian epithelial carcinoma and its implication HU Zhuo-ying1,LIN Xiao2 (1 Department of Obstetrics and Gynecology，the First Affiliated Hospital，2 Department of Pathology, Chongqing University of Medical Sciences, Chongqing, 400016) Abstract：Objective To investigate the expression of Wnt-1, beta-catenin and C-myc in normal ovarian epithelial cell and malignant ovarian epithelial tumor. Methods Immunohistochemical staining with SP method was conducted to identify ———————— 基金项目：重庆医科大学校级科研项目（XB200508） 作者简介：胡琢瑛,女,硕士研究生,主要从事妇科肿瘤的研究。电话 E－mail:huzhuoying@ expression of Wnt-1, beta-catenin and C-myc in normal epithelial cell and malignant ovarian epithelial tumor. Results The positive expression rate of Wnt-1 and C-myc occurred in 5.56% and 16.67% of 18 cases in normal ovarian epithelial , in 94.11% and 100% of 34 malignant ovarian epithelial tumor cases；the abnormal expression rate of beta-catenin occurred in 16.67% of 18 cases in normal ovarian epithelial ,100% of 34 malignant ovarian epithelial tumor cases. The expression of Wnt-1 and C-myc in malignant epithelial tumors were significantly higher than that in normal mature epithelial cell(P＜0.05). The abnormal expression of beta-catenin was significantly gre