氧化铁纳米颗粒在神经元组织工程中的应用.docVIP

氧化铁纳米颗粒在神经元组织工程中的应用 脊髓损伤、周围神经长段损失或脑病变后，神经系统均很难自身修复。神经元组织工程研究的目的是开发出替换损伤的神经组织，或增加神经系统的再生能力及恢复丢失功能的方法。以色列NVR研究公司研究人员与宜兰大学科学家合作，致力于研究开发用于急性和慢性脊髓损伤，及严重长节段周围神经损伤重建的植入物。 发表在《中国神经再生研究（英文版）》2015年 2 月 2期的一篇文章中，作者介绍了一种新的磁性纤维蛋白水凝胶支架的生物相容和生物可降解的氧化铁纳米颗粒，用2种方法合成铁氧化物纳米颗粒。第一种方法，通过逐步分层氧化铁-明胶核，制成平均干燥直径约20nm的明胶包被的铁氧化物纳米颗粒。在第二种方法中，将Fe2+和Fe3+的离子在氢氧化铵饱和的葡聚糖溶液进行沉淀,制成平均干燥直径大约10 nm的葡聚糖涂覆的氧化铁纳米颗粒。体外修复大鼠坐骨神经损伤的动物实验表明，该磁纤维蛋白凝胶支架可增强受损周围神经轴突的重建。此项研究受到由欧盟第七框架资助计划资助，相关体内试验正在计划进行中。 Article: Application of iron oxide anoparticles in neuronal tissue engineering by Ofra Ziv-Polat1, Shlomo Margel2, Abraham Shahar1 (1N.V.R Research Ltd., 11 Heharash St, Ness-Ziona 74031, Israel; 2Department of Chemistry, Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan 52900, Israel) Ziv-Polat O, Margel S, Shahar A (2015) Application of iron oxide anoparticles in neuronal tissue engineering. Neural Regen Res 10(2):189-191. 欲获更多资讯： 文章全文请见：Neural Regen Res Title Application of iron oxide nanoparticles in neuronal tissue engineering Summary statement Since the introduction of nanotechnology, nanoscale materials have been developed rapidly and applied in various fields. Recently Israeli scientists have reported in the journal of Neural Regeneration Research on the development of bioactive magnetic iron oxide nanoparticles (IONPs) for neuronal tissue engineering. This includes the development of a biocompatible and biodegradable magnetic scaffold which supports three-dimensional growth of regenerated neuronal tissue, and the development?of neurotrophic factors conjugated to IONPs with prolonged stability and biological activity. Body The nervous system is unable to repair by itself damages which caused for example, following spinal cord injuries, long segment loss of peripheral nerve, or diseased brain. The neuronal tissue engineering field aimed to develop strategies to replace damaged neural tissue, or to increase the regenerative capacity of the nervous system and restore lost functio