钛铌锆β钛合金低弹性模量内固定材料的生物相容性研究_医学论文.docVIP

钛铌锆β钛合金低弹性模量内固定材料的生物相容性研究_医学论文 钛铌锆β钛合金低弹性模量内固定材料的生物相容性研究_医学论文 【摘要】 目的］通过体内实验的方法对新型β型钛合金（Ti）骨折内固定材料的生物相容性进行评价。［方法］（1）改良的鼠气囊模型（the air pouch model）：健康成年SD大鼠24只，皮下充气造模后将钛铌铣β型钛合金（Ti）颗粒混悬液注入气囊，收集囊内液体采用ELISA方法测定IL和TNF，用囊壁组织学切片进行炎症细胞反应分级和囊壁厚度测量，并与传统的钛铅钒合金（Ti）进行比较。（2）接骨板植入模型：将Ti做成接骨板固定在兔的胫骨上，于手术后4、8、12、24、36周分别观察接骨板周围的纤维膜形成情况和Ti骨界面骨结合情况，并与不锈钢接骨板比较。［结果］（1）Ti、Ti两种颗粒注入气囊48 h后都能引起TNF分泌量显著升高（0），两组比较，Ti组明显高于Ti组（0）。两种材料均不能引起IL分泌的显著增加（Pgt0）。Ti组气囊囊壁厚度明显小于Ti组（0）。（2）Ti接骨板周围软组织反应与不锈钢相近。植入后4周，新生骨痂开始覆盖Ti接骨板的两侧，8周时骨痂甚至部分覆盖接骨板和螺钉的表面形成“骨盖板”现象。12周时，骨与Ti接骨板的界面为直接接触，中间无软组织间隔。螺钉与骨也能形成较为牢固的钉骨直接接触。［结论］低弹性模量Ti钛合金具有优良的体内组织相容性，是一种有前途的骨折内固定材料。 【关键词】 内固定　钛铌锆　生物相容性材料　体内研究 Abstract［Objective］To develop new beta titanium alloys made of titanium, niobium and zirconium (Ti［Method］(1) 24 SD rats were used in the modified air pouch model experimentsamination All the results were compared with Ti6Al4V (2) TiNbZr bone plates were fixed onto tibias of rabbits The capsules around the plates and the bone under them were observed at 4, 8, 12, 24 and 36 weeks respectively TiNbZrbone interfaces were emphasized in this procedure This time the control material was stainless steel ［Result］(1)Ti TiNbZr particles did (005) This effect was not seen in IL6 menstruations experiments The thickness of the air pouches was different in two groups It was thinner in the TiNbZr group than that in Ti6Al4V group (0001)(2)After 4 weeks of TiNbZr bone plates implantation the new callus formed beside the plates The “callus overlay the plate” phenomenon was seen after 8 weeks In 12 weeks a kind of direct integration had formed in the boneplates interfaces No soft tissue was seen in them The same direct integration was also seen in the bonescrew interfaces ［Conclusion］The Tierial for internal fixation instruments Key words：internal fixaiontitanium 作者自行研制了低弹性模量钛铌锆β型（Ti）合金〔1〕，在体外生物相容性实验取得良好结果的基础上，进一步对其体内生物相容性进行进一步的评价。考虑到Ti作为骨折内固定材料的具体应用前景，实验将贾庆卫等 〔3〕的大鼠气囊模型（the air pouch model）应用于Ti材料的生物相容性的评价，并将Ti制成