正常人不确定奖赏抉择加工激活脑区的分析.docVIP

Brain areas activated by uncertain reward-based decision-making in healthy volunteers**** Zongjun Guo1, 2, Juan Chen1, 2, Shien Liu2, 3, Yuhuan Li4, Bo Sun4, Zhenbo Gao4 1 Special Health Care Department, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong Province, China 2 The Institute of Brain Science Human Resource Management of Qingdao University, Qingdao 266003, Shandong Province, China 3 Department of Medical Imaging, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong Province, China 4 Qingdao Mental Health Center, Qingdao 266034, Shandong Province, China Research Highlights (1) Compared with decision-making in the ‘certain’ condition, the ventrolateral prefrontal lobe, frontal pole of the prefrontal lobe, orbitofrontal cortex, precentral gyrus, inferior temporal gyrus, fusiform gyrus, supramarginal gyrus, inferior parietal lobule, and cerebellar posterior lobe exhibited greater activation in the ‘risk’ condition. Compared with decision-making in the ‘certain’ condition, the frontal pole of the prefrontal lobe was strongly activated in the ‘ambiguous’ condition. Compared with the ‘risk’ condition, the dorsolateral prefrontal lobe and cerebellar posterior lobe showed significantly greater activation in the ‘ambiguous’ condition. (2) The activation of brain areas related to the processing information about loss increased with the degree of uncertainty. Abstract Reward-based decision-making has been found to activate several brain areas, including the ventrolateral prefrontal lobe, orbitofrontal cortex, anterior cingulate cortex, ventral striatum, and mesolimbic dopaminergic system. In this study, we observed brain areas activated under three degrees of uncertainty in a reward-based decision-making task (certain, risky, and ambiguous). The tasks were presented using a brain function audiovisual stimulation system. We conducted brain scans of 15 healthy volunteers using a 3.0T magnetic reso