国产rhFSH与果纳芬对排卵障碍患者促排卵的临床观察_临床医学论文.docVIP

国产rhFSH与果纳芬对排卵障碍患者促排卵的临床观察_临床医学论文 国产rhFSH与果纳芬对排卵障碍患者促排卵的临床观察_临床医学论文 作者：贺艳坤，徐雯， 卢伟英，周雪梅，黄元华 【摘要】 　　目的：比较国产重组人促卵泡激素（rhFSH）（金赛药业）与果纳芬（雪兰诺公司）对排卵障碍的不孕患者促排卵治疗的疗效，评价国产rhFSH 的治疗作用，了解卵泡生长速率及生殖内分泌激素水平变化的规律。方法：将排卵障碍不孕患者 54例随机分为A组34例、B组20例，进行促排卵治疗，A组给予国产rhFSH促排卵，B组给予果纳芬促排卵，观察两组疗效。结果：A、B两组的用药总量、平均每日用药量、平均促排卵天数、HCG日≥18mm卵泡数目、优势卵泡平均生长速率、HCG日血E2、LH、P水平、HCG日子宫内膜厚度、排卵后6d的P值、排卵率、妊娠率、分娩率分别为（1062.5±505.7）（375～2175）IU和（1157.5±470.6） (375～2325)IU； （105.8±28.2）（75～150）IU和（114.9±30.3）（75～150）IU；（10.0±4.3）（5～20）d和(10.4±4.0)（5～20）d； (1.3±0.7)个和(1.3±0.6)个；(1.7±0.2)mm/d和(1.5±0.2)mm/d；(2283.1±2350.0)pg/mL，(6.9±5.4)pg/mL，(1.4±1.2)ng/mL和(2098.2±2454.2)pg/mL，(8.4±5.8)pg/mL，(1.3±0.8)ng/mL；(10.7±0.4)mm和(10.3±0.7)mm；(31.7±37.8)ng/mL和(33.3±29.1)ng/mL； 82.4% 和90.0%；17.6%和25.0%，66.7%和80.0% (Pgt;0.05)。结论:国产rhFSH具有良好的促排卵疗效，身体反应过程一致，作用不弱于果纳芬。 【关键词】 重组人促卵泡刺激素；促排卵；卵泡生长速率；不育症 ［ABSTRACT］ Objective:To compare ovulation induction effect of domestic rhFSH(GenSci) and Gonal（Serono） on ovulation disorders, and evaluate the effect of rhFSH on follicular growth and reproductive hormones. Methods: Fiftyn days, number of follicles greater than 18 mm, follicular development velocity, blood estrodiol, lutinizing hormone, progesterone level on HCG day, endometrial thickness on HCG day,progesterone level after ovulation for 6 days，ovulation rate, pregnancy rate of group A and B were 1062.5±505.7（375）IU VS 1157.5±470.6, (375（75）IU VS 114.9±30.3,（75）IU; 10.0±4.3,（5）day VS 10.4±4.0,（5）day; 1.3±0.7VS1.3±0.6; (1.7±0.2) mm/d VS (1.5±0.2) mm/d; (2283.1±2350.0) pg/mL，(6.9±5.4) pg/mL，(1.4±1.2) ng/mL VS (2098.2±2454.2) pg/mL，(8.4±5.8) pg/mL, (1.3±0.8) ng/mL; (10.7±0.4)mm VS (10.3±0.7)mm; (31.7±37.8) ng/mL VS (33.3±29.1) ng/mL ; 82.4% VS 90%; 17.6% VS 25%; 66.7% VS 80%(Pgt;0.05).Conclusion: Domestic rhFSH is as effective as t GonalF. ［KEY WORDS］ Recombinant human follicle stimulating hormone; Ovulation induction; Follicle growth velocity; Infertility 重组人促卵泡激素（recombinant human follicle stimulating hormone, rhFSH）［1］是以真核细胞为载体，将人FS