慢性肺心病患者血浆抵抗素水平变化及其意义_临床医学论文.docVIP

慢性肺心病患者血浆抵抗素水平变化及其意义_临床医学论文 慢性肺心病患者血浆抵抗素水平变化及其意义_临床医学论文 作者：李慧，刘玲娟，张娟，徐华，曹军，唐朝枢，李桂忠 【摘要】 　　目的 探讨抵抗素（resistin）血浆水平变化与慢性肺心病之间的关系及其意义。方法 选择慢性肺心病病人（CPHD组）22例，慢性阻塞性肺疾患组（COPD组）22例和32例健康人作为正常对照，放射免疫分析检测血浆resistin含量（ng·L-1）。结果 COPD组病人的抵抗素浓度较正常对照组降低（P＜0.01），右下肺动脉横径、右室流出道内径较正常对照组显著增大（P＜0.01），右室前壁厚度与抵抗素浓度存在正相关（r=0.541，P＜0.01）；CPHD组的病人抵抗素浓度较正常对照组和COPD组均显著降低（P＜0.01）；CPHD组的病人右下肺动脉横径、右室流出道内径、右室前壁厚度较正常对照组和慢性阻塞性肺疾患组均显著升高（P＜0.01），右室流出道内径与抵抗素浓度水平存在正相关（r=0.477，P＜0.05）。结论 血浆抵抗素水平可作为监测慢性肺心病发生的早期标志物，用于慢性肺心病的早期诊断和预防。 【关键词】 抵抗素；慢性肺心病；放射免疫 　　Abstract: Objective To investigate the significance and levels of plasma resistin in patients with chronic pulmonary heart disease. Methods Plasma resistin levels were determined by radioimmunoassay in all patients and 28 normal controls. Results Compared to normal controls, the concentrations of plasma resistin in patients with chronic obstructive pulmonary disease were significantly decreased (P＜0.01), right bottom pulmonary artery diameter and right ventricle out flow tract diameter were increased significantly (P＜0.01), right ventricle anterior wall depth was significantly positive correlated to the concentrations of plasma resistin (r=0.541, P＜0.01). Compared to normal controls and patients with chronic obstructive pulmonary disease, the concentrations of plasma resistin was increased markedly (P＜0.01), right bottom pulmonary artery diameter, right ventricle out flow tract diameter and right ventricle anterior wall depth in patients with chronic pulmonary heart disease were increased significantly (P＜0.01), right ventricle out flow tract diameter was significantly positive correlated to the concentrations of plasma resistin (r=0.477, P＜0.05). Conclusion Measurements of the plasma resistin concentrations is useful to serve as early markers of right ventricular hypertrophy, and abnormalities of right ventricular function and hypertrophy in patients with chronic pulmonary heart disease in daily clinical practice. 　　Key words： resistin；chronic pulmonary