三氧治疗放射性肠炎.docVIP

三氧直肠灌注治疗放射性肠炎的临床观察 张涛 王伟 肖锋 游俊云 孙春影 张欣婷 （广州中医药大学祈福医院） 【摘要】目的：观察三氧直肠灌注治疗放射性肠炎的临床疗效及不良反应。方法：将70例确诊放射性肠炎的患者随机分为2组（治疗组，对照组）。治疗组35例，接受三氧直肠灌注治疗；对照组35例，接受地塞米松10mg+250ml生理盐水保留灌肠治疗。治疗1疗程后观察两组疗效及不良反应。结果：治疗组放射性肠炎症状明显缓解，且疗效优于对照组（P0.05），未见明显不良反应。结论：三氧直肠灌注治疗放射性肠炎安全有效。 【关键词】三氧直肠灌注 放射性肠炎 临床观察 Clinical Observation on Medical Ozone Rectal Perfusion Treating Patients with Radiation Enterocolitis Zhang Tao, Wang Wei, Xiao Feng, You Junyun, Sun Chunying, Zhang Xinting (Clifford Hospital, Guangzhou, Guangdong) Abstract Objective: Observe the curative effects and adverse reactions of medical ozone rectal perfusion treating patients with radiation enterocolitis. Method: 70 patients diagnosed radiation enterocolitis were randomly divided into 2 groups (Treatment Group and Control Group). Treatment Group with 35patients in it was treated with medical ozone rectal perfusion, and Control Group with 35 patients in it was treated with 10mg Dexamethasone+ 250ml physiological saline retention enema. Curative effects and adverse reactions were observed and recorded after 1 cycle of treatments. Results: Radiation enterocolitis were obviously relieved in Treatment Group, and the curative effect was significantly better than Control Group (P0.05). No obvious adverse reaction was observed in the observation of treatments. Conclusion: Medical ozone rectal perfusion has safe and reliable curative effect on treating patients with radiation enterocolitis. Key Words: Medical ozone rectal perfusion, Radiation enterocolitis, Clinical observation 放射治疗是恶性肿瘤治疗的主要手段之一，随着目前放疗技术的发展，广泛应用于恶性肿瘤治疗，辅助性、根治性、姑息性放疗均已获得肯定疗效，尤其是鼻咽癌、宫颈癌等为主要治疗方式，疗效肯定。放射性炎症为放疗常见并发症，可发生在治疗后数周乃至数年。放射性肠炎为行腹盆腔放射治疗患者的主要并发症，临床症状可表现为腹泻，可伴有便血、腹部绞痛等。目前临床上治疗放射性肠炎多采用保留灌肠。我院使用三氧直肠灌注（三氧气体保留灌肠）治疗放射性肠癌疗效满意，现报告如下： 资料与方法 1 临床资料：70例患者均为2010年6月至2012年6月在我院肿瘤中心住院治疗的恶性肿瘤患者，其中男性22例，女性48例，年龄24-65岁，平均年龄43.5±7.8岁。均经病理学及影像学确诊为腹腔恶性肿瘤，已行根治性或姑息性放疗，G-6-PD缺乏症患者，三氧过敏者，并发肠梗阻或肠道穿孔者，治疗依从性差者。 4 盲法：采用单盲法，受试者不知道自己被分配到治疗组或对照组。为避免产生偏倚，实验操作人员与疗效评价人员、数据分析人员分开。 5 治疗方法 5.1 三氧直肠灌注：仪器为德国霍