肝素功能化生物材料的研究进展.pdfVIP

2010 年第 30 卷 有 机 化 学 Vol. 30, 2010 第 3 期, 359～367 Chinese Journal of Organic Chemistry No. 3, 359～367 ·综述与进展· 肝素功能化生物材料的研究进展 李 娟a 吴英锋b 杨新林*,a (a 北京理工大学生命科学与技术学院 北京 100081) (b 北京市首都医科大学宣武医院血管外科 北京 100053) 摘要 从物理吸附涂层、共价键连接和微载体控释等方面综述了肝素功能化生物材料的最新研究进展. 大量研究表明 这些肝素材料具有抗凝血和/或生长因子释放的功能, 但未来的研究重点是构建各种控制释放肝素亲和性生长因子的 系统. 关键词 肝素; 生长因子; 功能化; 生物材料 Progress in Heparin-Functionalized Biomaterials Li, Juana Wu, Yingfengb Yang, Xinlin*,a a ( School of Life Science and Technology, Beijing Institute of Technology, Beijing 100081) (b Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053) Abstract Ths recent progress in heparin-functionalization of biomaterials is reviewed. Achievements in materials preparation based on physical adsorption coatings, covalent graft and biomimetic microcarriers are included. All these heparin-containing materials have antithrombogenicity and/or can control the release of growth factors, which have been extensively investigated. However, the research in the near future will fo- cus on construction of various systems to control the release of heparin affinitive growth factors. Keywords heparin; growth factor; functionalization; biomaterial 肝素是一种天然生物活性多糖类化合物, 具有很强 1 肝素结构与生物活性 的抗凝血性. 采用肝素功能化来提高医用高分子材料的 抗凝血性能已经有几十年的历史. 肝素通过和抗凝血酶 1.1 结构 III (antithrombin III, AT-III) 、肝素结合蛋白(heparin in- 肝素(Heparin)于 1935 年首先被提纯并命