超声心动图与脑利钠肽在川崎病不同时期临床诊断价值_张树华.pdfVIP

·8 · 　Prevent ion and Treat ment of Cardio-Cerebral-Vascular Disease　Feb 2013.　Vol 13.　No 1　 ·临床研究· 超声心动图与脑利钠肽在川崎病 不同时期临床诊断价值 1 1 1 2 1 1 张树华,张俊玲, 闫晓燕,暴瑞丽, 王　彬,刘　牧 [摘　要]　目的　探讨超声心动图与脑利钠肽(brain natriuretic peptide, BNP)在川崎病(kawasaki Disease, KD)中的临床 诊断价值, 为川崎病不同时期采用不同的检查方法进行诊断提供科学依据。方法　选取川崎病患儿35 例为川崎病 组, 以发热、皮疹为 诉的肺炎支原体或病毒感染的48 例患儿为对照组, 用超声心动图检测急性期与恢复期左、右冠 状动脉内径, 同时, 检测血中脑利钠肽水平, 并做相关性分析。结果　川崎病患儿恢复期冠状动脉内径值明显升高, 高 于对照组, 差异具有统计学意义(P0.05)。川崎病患儿急性期脑利钠肽高于对照组, 差异具有统计学意义(43.9 vs 15.8, P0.01)。恢复期川崎病患儿冠状动脉扩张比例显著高于急性期KD 患儿(P0.05);川崎病患儿急性期脑利 钠肽水平与恢复期左冠状动脉内径(L AID)、右冠状动脉内径(R AID)呈正相关(P0.05)。结论　超声心动图诊断 川崎病及冠状动脉扩张在恢复期更有临床意义;脑利钠肽可作为急性期诊断川崎病的生化指标之一;急性期脑利钠 肽值明显升高应警惕患儿恢复期冠状动脉扩张。 [关键词] 　心脏超声;冠状动脉扩张;川崎病;脑利钠肽 中图分类号:R725.4　　文献标识码:A　　文章编号:1009-816X(2013)01-0008-03 doi:10.3969/j.issn.1009-816X.2013.01.03 TheDiagnostic Significance of Echocardiography and Brain Natriuretic Peptide in Different Periods of Kawasaki Disease. ZHANGShu-hua, ZHANGJun-ling, YAN Xiao-yan, et al.Department of Pediatrics, The Hospital of Hebei nited niversity, Hebei 063000, China [Abstract] ObjectiveTo investigate the significance of echocardiography and brain natriuretic peptide (BNP, brain natriuretic peptide) in the diagnosis of the kawasaki disease, andto provide scientific basis for the diagnosis. ethods35 patientswith kawasaki disease for case groupwere enrolled, other 48 patientswith mycoplasma pneumoniae or virus infectionthat complaint of fever and rashwere enrolled as controlled group.We measured the left, right coronary artery diameter value and brainnatriuretic peptide value in acute and recovery phase respectively, and did correlation analysis.ResultsIn the recovery phase, the coronary artery d