心肌声学造影评价双嘧达莫和多巴酚丁胺对冠状动脉微循环的影响.pdfVIP

2000 12 80 12 N tl Med J Chin , December 2000, Vol 80, No. 12 939 宾建平 Kevin Wei Robert A. Pelberg 刘伊丽 查道刚 S njiv K ul ! ( MBF) ( MBV) 2 ( MCE) ( ) ∀ # 13 7~ 10 d, ( 0. 56 mg/ kg) ( 30~ 40 gkg- 1min- 1) , MBF MCE ( ∃ , MBV) ( ) 2 MBF (P 005) 2 , VI (P 0. 05) ; ( P 0. 05) ∃ , 2 (P 005) , ∃ MBF ( P 0. 000 1) , MBV , MBF , 2 MCE ! ; ; ; Assessment of the effects of dipyridamole and dobutamine on coronary microcirculation using myocardial * * contrast echocardiography BIN Jianping , Kevin Wei, Robert A . Pelberg , et al. Cardiovascular Division, Nanf ang Hospital, he First Military Medical University, Guangzhou 510515, Chin Abstract! Objectives To ev lu te the effects of dipyrid mole nd dobut mine on myoc rdi l blood flow ( MBF) nd myoc rdi l blood volume ( MBV) , nd their bility to detect nonflowlimiting coron ry stenoses with myoc rdi l contr st echoc rdiogr phy ( MCE) . Methods Thirteen closedchest dogs were studied t 710 d ys fter pl cement of meroid constrictors round proxim l coron ry rteries nd their br nches. MBF w s me sured with r diol beled microspheres nd myoc rdi l pl te u video intensity ( ∃ , which indic tes rel tive MBV) nd microbubble velocity ( ) were me sured with MCE t rest, fter dipyrid mole ( 0. 56 mg/ kg) , nd during pe k dobut mine dose ( 30 ~ 40 gkg- 1min- 1) . Results The effects of both gents on MBF were simil r in bnorm l nd norm l segments. Pl te u VI incre sed more nd incre sed less with dobut mine th n dipyrid mole ( P 0. 05) , but the pl te u ∃ r tios nd r tios between bnorm l nd norm l segments were lmost identic l during both drugs (P NS) , resulting in simil r perfusion defects. Excellent line r rel tions were found between the pl te u VI r tio or r tio nd MBF ( derived from r diol beled