消疲怡神口服液对应激大鼠下丘脑__省略_体_肾上腺_胸腺轴影响的实验研究_王琳.pdfVIP

·116 · 2000 2 20 2 —— —＊ 王　琳　王天芳　康纯洁　刘晓兰　刘　燕　张翠珍　郑君芳 　　　:探讨消疲怡神口服液抗应激的作用 理。:观察了消疲怡神口服液对强制冷水游 泳大鼠模型血清单胺类物质、肾上腺抗坏血酸和下丘脑垂体单胺类递质含量及胸腺指数的影响。:消疲 怡神口服液可以拮抗应激所致血清多巴胺、5-羟色胺含量升高和肾上腺抗坏血酸含量降低, 使降低的下丘脑 垂体去甲肾上腺素、5-羟色胺含量回升,但对胸腺指数无明显影响。:消疲怡神口服液的作用 制与其 对 体下丘脑—垂体—肾上腺—胸腺轴的调节有关。 　消疲怡神口服液　强制冷水游泳　下丘脑—垂体—肾上腺—胸腺轴 Effects of Xiaopi Yishen Oral Liquid on Hypothalamus-Pituitary-Adrenal Gland-Thymus Axis in Stressed Rats WANG Lin, WANG Tianfang, KANG Chunjie, et al Beij ing Un iversity of Tr ad it ional Ch inese Med icine, Beij ing (100029 ) 　　O jective:To investigate the effe t of Xiaopi Yishen (XPYS )oral liquid on the rats under repeated for ed old w ater swimming (RFCWS)stress.Methods:The hanges of serum monoamine, as orbi a id levels in a- drenal gland, monoamine levels in hypothalamus and hypophy sis, and thymus index w ere determined.Results: XPYS lowered the in reasing of serum DA, 5-HT, improved the redu ing of as orbi a id in adrenal gland and NE, HVA, 5-HT, 5-HIT T in hypothalamus and hypophysis of RFCWS-stressed rats.Conclusion:The me ha- nism of XPYS is in onne tion w ith the regulation of hypothalamus-pituitary-adrenal gland-thymus ax is. 　　Key words　Xiaopi Yishen oral liquid, repeated for ed old w ater swimming, hypothalamus-pituitary-a- drenal gland-thymus axis 　　 (), , 。, 15 。 、、 2　　, (1) 。 、、、。 ,、 , :960928,: 10ml (1ml , , 1g )。 , ——— , :0.1g, ,, 25mg。 (E), 、 (NE ), (DA ), 5-(5-HT ), 。 (HVA ), 5- (5-HIAA ), 3 、4-