毕业设计（论文）-磁共振灌注成像中脑血容积的仿真研究.docVIP

毕业设计说明书 专业： 生物医学工程 题 目： 磁共振灌注成像中的脑血容积的仿真研究 指导者： 教授 评阅者： 实验师 2012年 6月 8日 毕业设计（论文）中文摘要 磁共振灌注成像中的脑血容积的仿真研究 摘要： 磁共振灌注成像是反映组织的微血管分布及血流灌注情况的毕业设计（论文）外文摘要 Title Simulation research on brain cerebral volume in MR perfusion imaging Abstract Magnetic resonance （MR）perfusion imaging is a functional imaging technology which shows the micro vascular scatters and blood perfusion situation .It can record the concentration change by observing the injected tracer, then obtain dynamic parameters reflecting cerebrum local blood flow according to the change of signal intension to achieve the purpose of disease prevention and diagnosis .Among them, the cerebral blood volume (CBV) is one of the most important blood flow dynamics parameters. In this thesis, the development course, basic theory and research significance of MRI are analyzed firstly. The Fourier Transform (FT), minimum mean-squared error (MMSE), singular value decomposition （SVD）technique are applied to simulate on the CBV. The filter by applying MMSE theory plays a key role in this research. The influence of the noise in signal can be eliminated effectively by setting the right threshold in SVD technique. At the same time， the experimental results of two methods are analyzed respectively, and the possible influencing factors summarized. Keywords：Fourier transform singular value decomposition  目 次 1 引言…………………………………………………………………………………………… 1 1.1 磁共振灌注成像的历史回顾与发展现状……………………………………… 1 3 1.3 磁共振灌注成像的临床应用与研究意义……………………………………… 5 1.4 本论文的主要研究工作…………………………………………………………6 2 基于傅里叶变换在磁共振灌注成像中脑血容积估计中的应用…………………6 2.1 傅立叶正反变换的数学原理 ……………………………………………………6 2.2 脑血容积仿真中傅立叶变换的应用 ……………………………………………7 2.3 仿真结果与分析…………………………………………………………………10 2.4 本章小结…………………………………………………………………………14 3 基于奇异值分解在磁共振灌注成像中脑血容积估计中的应用…………………14 3.1 奇异值分解的数学原理………………………………………………………14 3.2 脑血容量估计中SVD的应用……………………………………………………15 3.3 脑血容积仿真实验与结果分析…………………