链接化学和聚合 相关内容.docVIP

Prof. K. B. Sharpless, Prof. M. G. Finn Department of Chemistry The Scripps Research Institute 10550 North Torrey Pines Road La Jolla, CA 92037 (USA) Fax: (+1) 858-784-7562 E-mail: sharples@scripps.edu Dr. H. C. Kolb Vice President of Chemistry Coelacanth Corporation East Windsor, NJ 08520 (USA) Journal of Polymer Science: Part A: Polymer Chemistry, Vol. 44, 5699–5707 (2006) ABC-Type Hetero-Arm Star Terpolymers Through “Click” Chemistry 链接所需含炔化合物，同时含有ATRP引发剂、TEMPO引发剂 60oC ATRP MMA聚合、125oC TEMPO St聚合 80oC ATRP tBA聚合、末端转化成叠氮功能基 单羟基聚乙二醇PEG、对甲苯磺酰氯，将末端转化成对甲苯磺酰基，再转化成叠氮功能基 三臂不同聚合物主链的星型聚合物 Journal of Polymer Science: Part A: Polymer Chemistry, Vol. 44, 6458–6465 (2006) A3-Type Star Polymers via Click Chemistry Analytical Chemistry, Vol. 78, No. 14, July 15, 2006 4969-4975 “Click Chemistry” in the Preparation of Porous Polymer-Based Particulate Stationary Phases for μ-HPLC Separation of Peptides and Proteins The copper(I)-catalyzed (3 + 2) azide-alkyne cycloaddition, an element of the ?click chemistry” popularized by Sharpless’ group,7 is a very efficient coupling reaction that provides an ideal reactivity profile for this purpose. Equation 1 shows a general scheme of the Cu(I)-catalyzed reaction of a terminal alkyne with a terminal azide affording a 1,4-disubstituted triazole ring: Cu(I)催化的[3+2]叠氮-炔烃环加成是Sharpless研究小组广泛应用的链接化学的重要反应，是非常有效的偶联反应，能够保证理想的反应活性满足研究目的。该反应在有机化学中是1,4-二取代三唑环的合成方法，原料是末端炔烃和末端叠氮化合物。 This reaction has already been widely used for the synthesis of substituted triazoles in solution. 8-12 Because azide and alkyne functionalities do not interfere with common biological processes, the copper-catalyzed azide-alkyne cycloaddition has been used for profiling enzyme activity13-17 and to incorporate new functionalities in proteins,18 cells,19 and viruses.20 This “click” reaction was also applied for the preparation and functionalization of dendrimers21,22 as well as for the synthesis23 and modification24 of linear polymers. In addition, the utility of this reaction